Reconstitution of lipid droplet function (12+)

• Subject Area: Cell Biology
• Term: from 2010 to 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 112927078

This project aims at elucidating the role of acyl-carnitins in beta-oxidation and as signalling substances. With a newly developed assay we will trace fatty acids during beta-oxidation and follow with high time resolution and sensitivity the metabolism of the corresponding acyl-carnitins, as well as their transport between mitochondria and cytoplasm. Accumulation of acyl-carnitins is an indication of limiting capacity of beta-oxidation. Therefore, we will study a possible role of acyl-carnitins that are released from cells as signalling molecules in liver and adipose tissue.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 83: Molecular Architecture and Cellular Functions of Lipid/Protein Assemblies
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Co-Applicant Institution: Rheinische Friedrich-Wilhelms-Universität Bonn
• Project Head: Professor Dr. Christoph Thiele