ADAPtive T cell migration into the stressed brain (B12)

• Subject Area: Immunology
• Term: from 2010 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 97850925

The ADAP-SKAP55 proteins form a molecular complex that regulates adhesion and migration of T cells. Our findings from the 2nd funding period suggest a role of the two proteins in modulating membrane scaffolding and actin filament organization. We now plan to delineate their contribution to actin-mediated migration of T cells by structural, biochemical and molecular biology techniques. We will exploit our mechanistic insights to probe in mice the role of ADAP-SKAP55 as well as their interaction partners in stress-induced T cell extravasation into the brain meningeal space and clarify their relevance for T cell-supported cognitive functioning and coping with traumatic stress.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 854: Molecular Organisation of Cellular Communications within the Immune System
• Applicant Institution: Otto-von-Guericke-Universität Magdeburg
• Project Heads: Professor Dr. Christian Freund; Dr. Stefanie Kliche; Professor Dr. Burkhart Schraven, until 12/2017; Professor Dr. Oliver Stork, since 1/2018