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CTLA-4 (CD152)-induced signaling pathways as regulators of CD8+ T lymphocytes (B14)

Subject Area Immunology
Term from 2010 to 2021
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 97850925
 
To prevent immunopathology, differentiation of CD8+ T cells is tightly controlled by inhibitory receptors such as CTLA-4. Project B14, in collaboration with B16, identified by iTRAQ mass spectrometry novel signal transduction pathways downstream of CTLA-4 that will be further characterized in the 3rd funding period. In this respect, B14 will connect changes in cellular metabolism with altered T cell functions. The role of CTLA-4-mediated TCF-1 regulation in memory formation will be analyzed in a Listeria infection model in collaboration with A05. Furthermore, B14 will analyze the impact of CTLA-4 on JAML in the context of co-stimulation and adhesion in collaboration with B08 and B12.
DFG Programme Collaborative Research Centres
 
 

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