Control of immunological synapse formation in Tregs (B16)

• Subject Area: Immunology
• Term: from 2010 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 97850925

Regulatory T cells (Tregs) critically rely on the TCR signaling network to realize both their development and immunosuppressive function. This project will investigate the impact of newly identified candidate regulators of cytoskeleton dynamics and molecular transport for the unique assembly of TCR signaling components at the Treg-specific immunological synapse, and additionally will study the regulation and functional consequences of microvesicle transexocytosis from Tregs to antigen-presenting cells. Thereby, B16 will pave the way for targeting of molecular transport in Tregs to modulate their immunosuppressive properties.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 854: Molecular Organisation of Cellular Communications within the Immune System
• Applicant Institution: Otto-von-Guericke-Universität Magdeburg
• Project Heads: Professor Dr. Jochen Hühn; Professor Dr. Lothar Jänsch