Non-cellautonomous role of the endoribonuclease ENDU-2/ENDOU/PP11 in tumorigenesis and invasion (A06)

• Subject Area: Cell Biology
• Term: from 2010 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 89986987

A model for stem cell reprogramming and hyperproliferation by microenvironmental factors was established in C. elegans that additionally allows for studies of migration and invasion of tumor cells from their niche. The endoribonuclease ENDU-2 is sufficient for the induction of germline tumorigenesis and will be studied by a combination of biochemical and genetic experiments in C. elegans and human cell culture.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 850: Control of Cell Motility in Morphogenesis, Cancer Invasion and Metastasis
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Head: Professor Dr. Ralf Baumeister