Project Details
Projekt
Therapeutic impact of protease deficiency on breast cancer invasion and metastasis (B07)
Subject Area
Cell Biology
Term
from 2010 to 2021
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 89986987
To address whether the lysosomal proteases cathepsin B and D are essential for mammary cancer progression and tumor maintenance inducible Cre systems allowing for defined onsets of protease deficiencies in cancer or stromal cells will be employed. Interference of deficiencies with targeting PI3K/mTOR will be studied, since mTOR signaling is frequently dysregulated in breast cancer and the mTOR complex is associated with lysosomal membranes.
DFG Programme
Collaborative Research Centres
Applicant Institution
Albert-Ludwigs-Universität Freiburg
Project Heads
Professor Dr. Christoph Peters; Professor Dr. Thomas Reinheckel
