ErbB, Src and interactive signaling pathways in esophageal cancers (C05)

• Subject Area: Anatomy and Physiology
• Term: from 2010 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 89986987

The applicants previously showed that invasion of non-neoplastic, esophageal epithelial cells is inducible by controlled activation of HER2 homo- or HER2/HER3 heterodimers, with Src-family signaling involvement. In the current project they plan to study how Src/SFK signaling influences cell migration and invasion and if there are cell intrinsic counter-regulatory mechanisms, such as the metastasis suppressor KAI1/CD82, to ErbB- and Src-associated signaling. In a second step, they will analyze the external effects of the tumor cell milieu on their invasive and metastatic potential, focusing on the Hippo pathway and YAP.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 850: Control of Cell Motility in Morphogenesis, Cancer Invasion and Metastasis
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Head: Professorin Dr. Silke Laßmann