Lysosomal phospholipases of macrophages in antimicrobial defence

• Antragsteller: Professor Dr. Ulrich E. Schaible
• Fachliche Zuordnung: Parasitologie und Biologie der Erreger tropischer Infektionskrankheiten
• Förderung: Förderung von 2010 bis 2015
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 166360413

Macrophages patrol epithelial surfaces such as the alveolar lung epithelia for detection and eliminati-on of pathogenic invaders. One of the most important antibacterial effectors of macrophages is phagocytosis and lysosomal killing and degradation of engulfed microbes. We will study two lysosomal phospholipases of macrophages for their function in antibacterial host response against lung infections such as tuberculosis in vitro and in vivo. Both enzymes were recently identified and preliminary data indicate their specificity to attack bacterial membranes and affect on bacterial infections. Employment of biochemical and molecular techniques combined with knock out mice and infection models will reveal the function of these enzymes.

• DFG-Verfahren: Sachbeihilfen