Fate determinants for neuronal diversity in the adult telencephalon (A03)

• Subject Area: Molecular Biology and Physiology of Neurons and Glial Cells ; Developmental Neurobiology
• Term: from 2010 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 118803580

Recently, we characterized the progeny of individual neural stem cells (NSCs) of the mouse adult subependymal zone (SEZ) in vivo, using clonal analysis. This analysis revealed a markedly fast lineage expansion, limited NSC self-renewal and their consequential exhaustion during a few weeks. In the next funding period, we will use established clonal methods to assess changes in the neuronal output of individual stem cells after we trigger a widespread depletion of mature dopaminergic neurons in the olfactory bulb or an enriched olfactory environment.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 870: Assembly and Function of Neuronal Circuits in Sensory Processing
• Applicant Institution: Ludwig-Maximilians-Universität München
• Project Heads: Professorin Dr. Magdalena Götz, until 12/2013; Professor Dr. Jovica Ninkovic