Functional characterization of the balance between the major cytoplasmic poly(A) polymerase GLD-2 and deadenylases in C. elegans germ cells.

• Applicant: Professor Dr. Christian R. Eckmann
• Subject Area: Developmental Biology
• Term: from 2010 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 169324141

• Final Report Year: 2021

No abstract available

Publications

• Structural basis for the activation of the C. elegans noncanonical cytoplasmic poly(A)-polymerase GLD-2 by GLD-3. Proc Natl Acad Sci USA 112, 8614–8619 (2015)
  Nakel, Katharina; Bonneau, Fabien; Eckmann, Christian R. & Conti, Elena
  
• Polar Positioning of Phase-Separated Liquid Compartments in Cells Regulated by an mRNA Competition Mechanism. Cell 166, 1572–1584.e16 (2016)
  Saha, Shambaditya; Weber, Christoph A.; Nousch, Marco; Adame-Arana, Omar; Hoege, Carsten; Hein, Marco Y.; Osborne-Nishimura, Erin; Mahamid, Julia; Jahnel, Marcus; Jawerth, Louise; Pozniakovski, Andrej; Eckmann, Christian R.; Jülicher, Frank & Hyman, Anthony A.
  
• Structural basis for the antagonistic roles of RNP-8 and GLD-3 in GLD-2 poly(A)- polymerase activity. RNA 22, 1139–1145 (2016)
  Nakel, Katharina; Bonneau, Fabien; Basquin, Claire; Habermann, Bianca; Eckmann, Christian R. & Conti, Elena
  
• Polyadenylation is the key aspect of GLD-2 function in C. elegans. RNA 23, 1180–1187 (2017)
  Nousch, Marco; Minasaki, Ryuji & Eckmann, Christian R.
  
• Stage-specific combinations of opposing poly(A) modifying enzymes guide gene expression during early oogenesis. Nucleic Acids Res 47, 10881–10893 (2019)
  Nousch, Marco; Yeroslaviz, Assa & Eckmann, Christian R.
  
• Stage-specific combinations of opposing poly(A) modifying enzymes guide gene expression during early oogenesis. Nucleic Acids Res 47, 10881–10893 (2019)
  Nousch, Marco; Yeroslaviz, Assa & Eckmann, Christian R.