Functional characterization of the balance between the major cytoplasmic poly(A) polymerase GLD-2 and deadenylases in C. elegans germ cells.

• Applicant: Professor Dr. Christian R. Eckmann
• Subject Area: Developmental Biology
• Term: from 2010 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 169324141

• Final Report Year: 2021

Final Report Abstract

No abstract available

Publications

• Structural basis for the activation of the C. elegans noncanonical cytoplasmic poly(A)-polymerase GLD-2 by GLD-3. Proc Natl Acad Sci USA 112, 8614–8619 (2015)
  Nakel, K., Bonneau, F., Eckmann, C. R. and Conti, E.
  
• Polar Positioning of Phase-Separated Liquid Compartments in Cells Regulated by an mRNA Competition Mechanism. Cell 166, 1572–1584.e16 (2016)
  Saha, S., Weber, C.A., Nousch, M., Adame-Arana, O., Hoege, C., Hein, M.Y., Osborne Nishimura, E., Mahamid, J., Jahnel, M., Jawerth, L., Pozniakovski, A., Eckmann, C. R., Jülicher, F. and Hyman, A.A.
  
• Structural basis for the antagonistic roles of RNP-8 and GLD-3 in GLD-2 poly(A)- polymerase activity. RNA 22, 1139–1145 (2016)
  Nakel, K. Bonneau, F., Basquin, C., Habermann, B., Eckmann, C. R. and Conti, E.
  
• Polyadenylation is the key aspect of GLD-2 function in C. elegans. RNA 23, 1180–1187 (2017)
  Nousch, M., Minasaki, R. and Eckmann, C. R.
  
• Stage-specific combinations of opposing poly(A) modifying enzymes guide gene expression during early oogenesis. Nucleic Acids Res 47, 10881–10893 (2019)
  Nousch, M., Yeroslaviz, A. and Eckmann, C. R.
  
• Stage-specific combinations of opposing poly(A) modifying enzymes guide gene expression during early oogenesis. Nucleic Acids Res 47, 10881–10893 (2019)
  Nousch, M., Yeroslaviz, A. and Eckmann, C. R.