Cortical and basal ganglia contributions to the acquisition of sequential behavior: A neurostimulation, modeling, magneto- and electroencephalographic approach.
Final Report Abstract
This project shed new light on our understanding of the processes and brain mechanisms mediating learning and monitoring of sensorimotor sequences, both in patients with movement disorders and in healthy human subjects. Using piano performance as experimental setup, we were able to investigate the neural mechanisms at the cortical and subcortical level engaged in (i) the encoding of sequence boundaries, (ii) the integration between auditory and motor information during sequence learning, (iii) the control of the timing of a skilled performance, (iv) how processing interoceptive cardiac signals influences error-monitoring. The results significantly expand the knowledge on the human action-monitoring system along two lines. Firstly, they provide new information about the cortical and subcortical processes associated with monitoring acquisition and execution of action sequences. Secondly, they also emphasise the need to consider interoceptive signals and brain-body interactions in these investigations. Furthermore, the data help elucidate the functional significance of basal ganglia and cortical oscillations.
Publications
- (2018) Disruption of Boundary Encoding During Sensorimotor Sequence Learning: An MEG Study. Frontiers in human neuroscience 12 240
Michail, Georgios; Nikulin, Vadim V.; Curio, Gabriel; Maess, Burkhard; Herrojo Ruiz, María
(See online at https://doi.org/10.3389/fnhum.2018.00240) - Encoding of sequence boundaries in the subthalamic nucleus of patients with Parkinson’s disease (2014). Brain 137 (Pt 10): 2715-30
Herrojo Ruiz M, Rusconi M, Brücke C, Haynes JD, Schönecker T, Kühn AA
(See online at https://doi.org/10.1093/brain/awu191) - Long-range correlation properties in timing of skilled piano performance: the influence of auditory feedback and deep brain stimulation. (2014). Frontiers in Psychology 5:1030
Herrojo Ruiz M, Hong SB, Hennig H, Altenmüller E, Kühn AA
(See online at https://doi.org/10.3389/fpsyg.2014.01030) - Brain networks modulated by subthalamic nucleus deep brain stimulation. (2016). Brain 139(9):2503-15
Accolla EA, Herrojo Ruiz M, Horn A, Schneider GH, Schmitz-Huebsch T, Draganski B, Kuehn AA
(See online at https://doi.org/10.1093/brain/aww182) - Cingulate and Cerebellar Beta Oscillations are Engaged in the Acquisition of Auditory-Motor Sequences. (2017). Human Brain Mapping 38(10): 5161-5179
Herrojo Ruiz M, Maess B, Curio G, Nikulin V
(See online at https://doi.org/10.1002/hbm.23722) - Reply: Oscillatory coupling of the subthalamic nucleus in obsessive compulsive disorder. (2017). Brain 140(9): e56 e56
Accolla EA, Horn A, Herrojo Ruiz M, Neumann WJ, Kühn AA
(See online at https://doi.org/10.1093/brain/awx165)
