Project Details
Projekt
Assembly and activation of multimolecular signaling clusters in B lymphocytes (B05)
Subject Area
Biochemistry
Term
from 2010 to 2022
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 105286809
Antibody-mediated immune responses are initiated upon ligation of the B cell antigen receptor which activates intracellular signal chains by virtue of the adaptor protein SLP65. We discovered that the signaling competence of SLP65 requires a three-step multimerization process resulting in the formation of phase-separated supra-molecular clusters. The assembly of these cytosolic 'signalosomes' is driven by the SH3 domain scaffolding protein CIN85. Our project aims at corrobarating the developing concept of biophysical compartmentalization of intracellular signaling elements through phase separation.
DFG Programme
Collaborative Research Centres
Applicant Institution
Georg-August-Universität Göttingen
Project Heads
Professor Dr. Christian Griesinger; Professor Dr. Jürgen Wienands
