Regulatorische T-Lymphozyten beim Schlaganfall - vom endogenen Protektionsmechnismus zum Therapieansatz

• Applicant: Professor Dr. Roland Ernst Veltkamp
• Subject Area: Molecular and Cellular Neurology and Neuropathology
• Term: from 2010 to 2014
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 174982766

• Final Report Year: 2015

No abstract available

Publications

• Postischemic brain infiltration of leukocyte subpopulations differs among murine permananent and transient focal cerebral ischemia models. Brain Pathol 2013;23:34-44
  Zhou, Wei; Liesz, Arthur; Bauer, Henrike; Sommer, Clemens; Lahrmann, Bernd; Valous, Nektarios; Grabe, Niels & Veltkamp, Roland
  
• The immunology of acute ischemic stroke. Nat Rev Neurol 2012;8:401-410
  Chamorro A, Meisel A, Planas AM, Urra X, van den Beek D, Veltkamp R
  
• Boosting Regulatory T cells limits neuroinflammation in brain ischemia. J Neurosci 2013:17350-17623
  Liesz A, Zhou W, Hämmerling GJ, Garbi N, Karcher S, Mracsko E, Na SY, Backs J, Rivest S, Veltkamp R
  
• Stress mediators and immune dysfunction in patients with acute cerebrovascular diseases. PLoS One 2013 epub
  Liesz, Arthur; Rüger, Holger; Purrucker, Jan; Zorn, Markus; Dalpke, Alexander; Möhlenbruch, Markus; Englert, Stefan; Nawroth, Peter P. & Veltkamp, Roland
  
• Antigen dependently activated CD8+ T cells cause perforin mediated neurotoxicity in experimental stroke. J Neurosci 2014;34: 16784-16795
  Mracsko, Eva; Liesz, Arthur; Stojanovic, Ana; Lou, Wilson Pak-Kin; Osswald, Matthias; Zhou, Wei; Karcher, Simone; Winkler, Frank; Martin-Villalba, Ana; Cerwenka, Adelheid & Veltkamp, Roland
  
• Differential effects of sympathetic nervous system and hypothalamic-pituitary-adreanal axis on systemic immune cells after severe experimental stroke. Brain Behav Immun 2014;41: 200-209
  Mracsko, Eva; Liesz, Arthur; Karcher, Simone; Zorn, Markus; Bari, Ferenc & Veltkamp, Roland
  
• Intracerebral interleukin-10 injection modulates post-ischemic neuroinflammation. An experimental microarray study. Neurosci Lett 2014;579:18-23
  Liesz, Arthur; Bauer, Andrea; Hoheisel, Jörg D. & Veltkamp, Roland
  
• Amplification of regulatory T cells using a CD28 superagonist reduces brain damage after ischemic stroke in mice. Stroke 2015;46: 212-220
  Na, Shin-Young; Mracsko, Eva; Liesz, Arthur; Hünig, Thomas & Veltkamp, Roland
  
• DAMP signaling is a key pathway inducing immune modulation after brain injury. J Neurosci 2015,35: 583-598
  Liesz, Arthur; Dalpke, Alexander; Mracsko, Eva; Roth, Stefan; Zhou, Wei; Yang, Huan; Na, Shin-Young; Akhisaroglu, Mustafa; Fleming, Thomas; Eigenbrod, Tatjana; Nawroth, Peter P.; Tracey, Kevin J. & Veltkamp, Roland