Detailseite
Projekt
GRK 1715: Molekulare Signaturen adaptiver Stressreaktionen
Fachliche Zuordnung
Medizin
Förderung
Förderung von 2012 bis 2021
Projektkennung
Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 177710919
Erstellungsjahr
2022
Zusammenfassung der Projektergebnisse
"All things are poison and nothing is without poison, only the dose permits something not to be poisonous" - the famous dictum of Paracelsus is of formidable relevance in modern medicine and biology. Organisms are perpetually facing noxious insults but exhibit surprising diverse reaction patterns. Depending on the strength, frequency and quality of the stress stimuli biological individuals may react with increased vitality, future stress resistance or with injury and degeneration. Whereas a multitude of such specific stress responses has been observed in diverse biological systems the underlying molecular mechanisms are largely unknown. Our Research Training Group explored specific signalling reactions controlling the ambivalent reaction patterns of cells and organisms to stressful challenges. Adaptive responses to defined stress stimuli were analysed in a dose- and time-resolved manner. In the first funding period the results of our RTG significantly added to the understanding of the molecular reaction patterns of biological systems towards dose-dependent effects of stress. In the second funding period investigations of the dynamics of adaptive stress responses were considerably intensified. Specific use of advanced animal models of selected diseases allowed efficient exploitation of the results in prophylaxis and treatment of modern medicine. These efforts contributed to strengthening the collaborative research projects on Sepsis and Ageing within the research focus “Life” at in Jena. In conjunction with research groups from the Medical Faculty and the Faculty of Biological Sciences of the FSU and of the Leibniz Institute on Aging – Fritz Lipmann Institute (FLI) the RTG fostered cross-disciplinary PhD research projects in this innovative field of life sciences. As a main goal, the RTG aimed to provide young scientists with insight into the intimate interrelationship between fundamental biological phenomena such as life and death, disease and recovery and the underlying complex molecular processes. The wide spectrum of cellular and organismic models used by the participating groups afforded a deeper understanding of the dynamic reaction patterns of biological systems challenged by external insults. In order to reach these goals, the study programme of the RTG offered a multifaceted series of lectures, meetings, seminars and workshops as well as placements in laboratories of international cooperation partners. The RTG is affiliated with the Jena School of Molecular Medicine (JSMM), a certified member of the FSU Jena Graduate Academy.
Projektbezogene Publikationen (Auswahl)
- (2012) Histone deacetylase inhibitors block IFNγ-induced STAT1 phosphorylation. Cell Signal. 24: 1453-1460
Ginter T, Bier C, Knauer SK, Sughra K, Hildebrand D, Münz T, Liebe T, Heller R, Henke A, Stauber RH, Reichardt W, Schmid JA, Kubatzky KF, Heinzel T, Krämer OH
(Siehe online unter https://doi.org/10.1016/j.cellsig.2012.02.018) - (2012) Protein phosphatase PP6 is required for homology-directed repair of DNA double-strand breaks. Cell Cycle. 10: 1411-1419
Zhong J, Liao J, Liu X, Wang P, Liu J, Hou W, Zhu B, Yao L, Wang J, Li J, Stark JM, Xie Y, Xu X
(Siehe online unter https://doi.org/10.4161/cc.10.9.15479) - (2012) Role of adipose and hepatic atypical protein kinase C lambda (PKCλ) in the development of obesity and glucose intolerance. Adipocyte. 1: 203-214
Habegger K, Matzke D, Ottaway N, Hembree J, Holland J, Raver C, Mansfeld J, Müller TD, Perez-Tilve D, Pfluger PT, Lee SJ, Diaz-Meco M, Moscat J, Leitges M, Tschöp MH, Hofmann SM
(Siehe online unter https://doi.org/10.4161/adip.20891) - (2013) A de novo gain-of-function mutation in SCN11A causes loss of pain perception. Nat Genet. 45: 1399-1404
Leipold E, Liebmann L, Korenke GC, Heinrich T, Giesselmann S, Baets J, Ebbinghaus M, Goral RO, Stödberg T, Hennings JC, Bergmann M, Altmüller J, Thiele H, Wetzel A, Nürnberg P, Timmerman V, De Jonghe P, Blum R, Schaible HG, Weis J, Heinemann SH, Hübner CA, Kurth I
(Siehe online unter https://doi.org/10.1038/ng.2767) - (2013) High-density lipoprotein maintains skeletal muscle function by modulating cellular respiration in mice. Circulation. 128: 2364-2371
Lehti M, Donelan E, Abplanalp W, Al-Massadi O, Habegger K, Weber J, Ress C. Mansfeld J, Somvanshi S, Trivedi C, Keuper M, Ograjsek T, Striese C, Cucuruz S, Pfluger PT, Krishna R, Gordon SM, Silva RAGD, Luquet S, Castel J, Martinez S, D’Alessio D, Davidson WS, Hofmann SM
(Siehe online unter https://doi.org/10.1161/circulationaha.113.001551) - (2013) Merlin isoform 2 in neurofibromatosis type 2-associated polyneuropathy. Nat Neurosci. 16: 426-433
Schulz A, Baader SL, Niwa-Kawakita M, Jung MJ, Bauer R, Garcia C, Zoch A, Schacke S, Hagel C, Mautner VF, Hanemann CO, Dun XP, Parkinson DB, Weis J, Schröder JM, Gutmann DH, Giovannini M, Morrison H
(Siehe online unter https://doi.org/10.1038/nn.3348) - (2013) MYPT1 sustains centromeric cohesion and the spindle-assembly checkpoint. J Genet Genomics. 40: 575-578
Li J, Liu X, Liao J, Tian J, Wang J, Wang X, Zhang J, Xu X
(Siehe online unter https://doi.org/10.1016/j.jgg.2013.08.005) - (2013) Phosphoinositide 3-kinaseγ mediates microglial phagocytosis via lipid kinase independent control of cAMP. Neuroscience. 233: 44-53
Schmidt C, Schneble N, Müller JP, Bauer R, Perino A, Marone R, Rybalkin SD, Wymann MP, Hirsch E, Wetzker R
(Siehe online unter https://doi.org/10.1016/j.neuroscience.2012.12.036) - (2013) Regulation of Son of sevenless by the membraneactin linker protein ezrin. Proc Natl Acad Sci USA. 110: 20587-20592
Geißler KJ, Jung MJ, Riecken LB, Sperka T, Cui Y, Schacke S, Merkel U, Markwart R, Rubio I, Than ME, Breithaupt C, Peuker S, Seifert R, Kaupp UB, Herrlich P, Morrison H
(Siehe online unter https://doi.org/10.1073/pnas.1222078110) - (2013) Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide. Nat Chem Biol. 9: 693-700
Schmeisser K, Mansfeld J, Kuhlow D, Weimer S, Priebe S, Heiland I, Birringer M, Groth M, Segref A, Kanfi Y, Price NL, Schmeisser S, Schuster S, Pfeiffer AFH, Guthke R, Platzer M, Hoppe T, Cohen HY, Zarse K, Sinclair DA, Ristow M
(Siehe online unter https://doi.org/10.1038/nchembio.1352) - (2013) S-nitrosylation of HDAC2 regulates the expression of the chromatin-remodeling factor Brm during radial neuron migration. Proc Natl Acad Sci USA. 110: 3113-3118
Nott A, Nitarska J, Veenvliet JV, Schacke S, Derijck AA, Sirko P, Muchardt C, Pasterkamp RJ, Smidt MP, Riccio A
(Siehe online unter https://doi.org/10.1073/pnas.1218126110) - (2013) Trügerische Etiketten für Signalproteine. BIOspektrum. 19: 401-404
Schmidt C, Schneble N, Bauer R, Wetzker R
(Siehe online unter https://doi.org/10.1007/s12268-013-0330-0) - (2014) Characterization of coxsackievirus B3 replication in human umbilical vein endothelial cells. Med Microbiol Immunol. 203: 217-229
Kühnl A, Rien C, Spengler K, Kryeziu N, Heller R, Henke A
(Siehe online unter https://doi.org/10.1007/s00430-014-0333-6) - (2014) D-Glucosamine supplementation extends lifespan of nematodes and of aging mice. Nat Commun. 5: 3563
Weimer S, Priebs J, Kuhlow D, Groth M, Priebe S, Mansfeld J, Merry TL, Dubuis S, Laube B, Pfeiffer AF, Schulz TJ, Guthke R, Platzer M, Zamboni N, Zarse K, Ristow M
(Siehe online unter https://doi.org/10.1038/ncomms4563) - (2014) Functional conservation of suppressors of cytokine signaling proteins between teleosts and mammals: Atlantic salmon SOCS1 binds to JAK/STAT family members and suppresses type I and II IFN signaling. Dev Comp Immunol. 45: 177-189
Skjesol A, Liebe T, Iliev DB, Thomassen EI, Tollersrud LG, Sobhkhez M, Lindenskov Joensen L, Secombes CJ, Jørgensen JB
(Siehe online unter https://doi.org/10.1016/j.dci.2014.02.009) - (2014) p53-dependent and p53- independent anticancer effects of different histone deacetylase inhibitors. Br J Cancer. 110: 656-667
Sonnemann J, Marx C, Becker S, Wittig S, Palani CD, Krämer OH, Beck JF
(Siehe online unter https://doi.org/10.1038/bjc.2013.742) - (2014) Pathogenesis of human mitochondrial diseases is modulated by reduced activity of the ubiquitin/proteasome system. Cell Metab. 19: 642-52
Segref A, Kevei E, Pokrzywa W, Schmeisser K, Mansfeld J, Livnat-Levanon N, Ensenauer R, Glickman MH, Ristow M, Hoppe T
(Siehe online unter https://doi.org/10.1016/j.cmet.2014.01.016) - (2014) Phosphoinositide 3-kinaseγ affects LPS-induced disturbance of blood-brain barrier via lipid kinase-independent control of cAMP in microglial cells. Neuromolecular Med. 16: 704-713
Frister A, Schmidt C, Schneble N, Brodhun M, Gonnert FA, Bauer M, Hirsch E, Müller JP, Wetzker R, Bauer R
(Siehe online unter https://doi.org/10.1007/s12017-014-8320-z) - (2014) Reversible inactivation of CO dehydrogenase with thiol compounds. Biochem Biophys Res Commun. 447: 413-418
Kreß O, Gnida M, Pelzmann AM, Marx C, Meyer-Klaucke W, Meyer O
(Siehe online unter https://doi.org/10.1016/j.bbrc.2014.03.147) - (2014) Survivin and YM155: how faithful is the liaison? Biochim Biophys Acta. 1845: 202-220
Rauch A, Hennig D, Schäfer C, Wirth M, Marx C, Heinzel T, Schneider G, Krämer OH
(Siehe online unter https://doi.org/10.1016/j.bbcan.2014.01.003) - (2014) The fifth dimension of innate immunity. J Cell Commun Signal. 8: 363- 367
Schmidt C, Schneble N, Wetzker R
(Siehe online unter https://doi.org/10.1007/s12079-014-0246-6) - (2015) Aurora B- dependent phosphorylation of Ataxin-10 promotes the interaction between Ataxin-10 and Plk1 in cytokinesis. Sci Rep. 5: 8360
Tian J, Tian C, Ding Y, Li Z, Geng Q, Xiahou Z, Wang J, Hou W, Liao J, Dong MQ, Xu X, Li J
(Siehe online unter https://doi.org/10.1038/srep08360) - (2015) Branched-chain amino acid catabolism is a conserved regulator of physiological ageing. Nat Commun. 6: 10043
Mansfeld J, Urban N, Priebe S, Groth M, Frahm C, Hartmann N, Gebauer J, Ravichandran M, Dommaschk A, Schmeisser S, Kuhlow D, Monajembashi S, Bremer-Streck S, Hemmerich P, Kiehntopf M, Zamboni N, Englert C, Guthke R, Kaleta C, Platzer M, Sühnel J, Witte OW, Zarse K, Ristow M
(Siehe online unter https://doi.org/10.1038/ncomms10043) - (2015) Glucocorticoid receptor regulates accurate chromosome segregation and is associated with malignancy. Proc Natl Acad Sci USA. 112: 5479-5484
Matthews LC, Berry AA, Morgan DJ, Poolman TM, Bauer K, Kramer F, Spiller DG, Richardson RV, Chapman KE, Farrow SN, Norman MR, Williamson AJ, Whetton AD, Taylor SS, Tuckermann JP, White MR, Ray DW
(Siehe online unter https://doi.org/10.1073/pnas.1411356112) - (2015) Modulation of LSD1 phosphorylation by CK2/WIP1 regulates RNF168-dependent 53BP1 recruitment in response to DNA damage. Nucleic Acids Res. 43: 5936-5947
Peng B, Wang J, Hu Y, Zhao H, Hou W, Zhao H, Wang H, Liao J, Xu X
(Siehe online unter https://doi.org/10.1093/nar/gkv528) - (2015) PHD1 regulates p53-mediated colorectal cancer chemoresistance. EMBO Mol Med. 7: 1350-65
Deschoemaeker S, Di Conza G, Lilla S, Martín-Pérez R, Mennerich D, Boon L, Hendrikx S, Maddocks OD, Marx C, Radhakrishnan P, Prenen H, Schneider M, Myllyharju J, Kietzmann T, Vousden KH, Zanivan S, Mazzone M
(Siehe online unter https://doi.org/10.15252/emmm.201505492) - (2015) Regulation of endoplasmic reticulum turnover by selective autophagy. Nature. 522: 354-358
Khaminets A, Heinrich T, Mari M, Grumati P, Hübner AK, Akutsu M, Liebmann L, Stolz A, Nietzsche S, Koch N, Mauthe M, Katona I, Qualmann B, Weis J, Reggiori F, Kurth I, Hübner CA, Dikic I
(Siehe online unter https://doi.org/10.1038/nature14498) - (2015) RETRA exerts anticancer activity in Ewing's sarcoma cells independent of their TP53 status. Eur J Cancer 51: 841-851
Sonnemann J, Grauel D, Blümel L, Hentschel J, Marx C, Blumrich A, Focke K, Becker S, Wittig S, Schinkel S, Krämer OH, Beck JF
(Siehe online unter https://doi.org/10.1016/j.ejca.2015.02.016) - (2015) The actin nucleator Cobl is controlled by calcium and Calmodulin. PLoS Biol. 13: e1002233
Hou W, Izadi M, Nemitz S., Haag N, Kessels MM., Qualmann B
(Siehe online unter https://doi.org/10.1371/journal.pbio.1002233) - (2016) Disulfide cross-linking influences symbiotic activities of nodule peptide NCR247. Proc Natl Acad Sci U S A. 113: 10157-62
Shabab M, Arnold MF, Penterman J, Wommack AJ, Bocker HT, Price PA, Griffitts JS, Nolan EM and Walker GC
(Siehe online unter https://doi.org/10.1073/pnas.1610724113) - (2016) Nonlinear structured illumination using a fluorescent protein activating at the readout wavelength. PLoS One. 11: e0165148
Lu-Walther HW, Hou W, Kielhorn M, Arai Y, Nagai T, Kessels MM, Qualmann B, Heintzmann R
(Siehe online unter https://doi.org/10.1371/journal.pone.0165148) - (2016) Phagocytosis of bone marrow derived macrophages is controlled by phosphoinositide 3-kinase γ. Immunol Lett. 180: 9-16
Kresinsky A, Schneble N, Schmidt C, Frister A, Bauer R, Wetzker R, Müller JP
(Siehe online unter https://doi.org/10.1016/j.imlet.2016.09.014) - (2016) Phosphoinositide 3-kinase γ restrains neurotoxic effects of microglia after focal brain ischemia. Mol Neurobiol. 53: 5468-79
Schmidt C, Frahm C, Schneble N, Müller JP, Brodhun M, Franco I, Witte OW, Hirsch E, Wetzker R, Bauer R
(Siehe online unter https://doi.org/10.1007/s12035-015-9472-z) - (2016) The DNA damage response molecule MCPH1 in brain development and beyond. Acta Biochim Biophys Sin (Shanghai). 48: 678-85
Liu X, Zhou ZW, Wang ZQ
(Siehe online unter https://doi.org/10.1093/abbs/gmw048) - (2016) The residue at position 5 of the N-terminal region of Src and Fyn modulates their myristoylation, palmitoylation, and membrane interactions. Mol Biol Cell. 27: 3926- 3936
Gottlieb-Abraham E, Gutman O, Pai GM, Rubio I, Henis YI
(Siehe online unter https://doi.org/10.1091/mbc.e16-08-0622) - (2016) TSC loss distorts DNA replication programme and sensitizes cells to genotoxic stress. Oncotarget. 7: 85365-85380
Pai GM, Zielinski A, Koalick D, Ludwig K, Wang ZQ, Borgmann K, Pospiech H, Rubio I
(Siehe online unter https://doi.org/10.18632/oncotarget.13378) - (2016) TSC loss distorts DNA replication programme and sensitizes cells to genotoxic stress. Oncotarget. 7: 85365-85380
Pai GM, Zielinski A, Koalick D, Ludwig K, Wang ZQ, Borgmann K, Pospiech H, Rubio I
(Siehe online unter https://doi.org/10.18632/oncotarget.13378) - (2017) Assessment of HDACi-Induced Cytotoxicity. Methods Mol Biol. 1510: 23-45
Marx-Blümel L, Marx C, Kühne M, Sonnemann J
(Siehe online unter https://doi.org/10.1007/978-1-4939-6527-4_3) - (2017) Deciphering caveolar functions by syndapin III KO-mediated impairment of caveolar invagination. Elife. 6: e29854
Seemann E, Sun M, Krueger S, Tröger J, Hou W, Haag N, Schüler S, Westermann M, Huebner CA, Romeike B, Kessels MM, Qualmann B
(Siehe online unter https://doi.org/10.7554/elife.29854) - (2017) GFAT1 phosphorylation by AMPK promotes VEGF-induced angiogenesis. Biochem J. 474: 983-1001
Zibrova D, Vandermoere F, Göransson O, Peggie M, Mariño KV, Knierim A, Spengler K, Weigert C, Viollet B, Morrice NA, Sakamoto K, Heller R
(Siehe online unter https://doi.org/10.1042/bcj20160980) - (2017) Hormesis and defense of infectious disease. Int J Mol Sci. 18: 1273
Weis S, Rubio I, Ludwig K, Weigel C, Jentho E
(Siehe online unter https://doi.org/10.3390/ijms18061273) - (2017) Hormesis and defense of infectious disease. Int J Mol Sci. 18: 1273
Weis S, Rubio I, Ludwig K, Weigel C, Jentho E
(Siehe online unter https://doi.org/10.3390/ijms18061273) - (2017) Phosphoinositide 3-kinase γ ties chemoattractant- and adrenergic control of microglial motility. Mol Cell Neurosci. 78: 1-8
Schneble N, Schmidt C, Bauer R, Müller JP, Monajembashi S, Wetzker R
(Siehe online unter https://doi.org/10.1016/j.mcn.2016.11.002) - (2017) The E3 ubiquitin ligase APC/CCdh1 degrades MCPH1 after MCPH1-βTrCP2-Cdc25A-mediated mitotic entry to ensure neurogenesis. EMBO J. 36: 3666-3681
Liu X, Zong W, Li T, Wang Y, Xu X, Zhou ZW, Wang ZQ
(Siehe online unter https://doi.org/10.15252/embj.201694443) - (2018) Arginine methylation by PRMT2 controls the functions of the actin nucleator Cobl. Dev Cell. 45: 262-275.e8
Hou W, Nemitz S, Schopper S, Nielsen ML, Kessels MM, Qualmann B
(Siehe online unter https://doi.org/10.1016/j.devcel.2018.03.007) - (2018) Direct effects of Ca2+/calmodulin on actin filament formation. Biochem Biophys Res Commun. 506: 355-360
Izadi M, Hou W, Qualmann B, Kessels MM
(Siehe online unter https://doi.org/10.1016/j.bbrc.2018.07.159) - (2018) DNA-Damage-Induced Hormetic Responses, Chapter in book: The Science of Hormesis in Health and Longevity, Rattan SIS, Kyriazi M (Editor). Academic Press
Mägdefrau AS, Ludwig K, Weigel C, Köse N, Guerra GM, Dakhovnik A, Kosan C
(Siehe online unter https://doi.org/10.1016/B978-0-12-814253-0.00013-9) - (2018) DNA-Damage-Induced Hormetic Responses. Chapter in book: The Science of Hormesis in Health and Longevity, Rattan SIS, Kyriazi M (Editor). Academic Press
Mägdefrau AS, Ludwig K, Weigel C, Köse N, Guerra GM, Dakhovnik A, Kosan C
(Siehe online unter https://doi.org/10.1016/B978-0-12-814253-0.00013-9) - (2018) DNA-Damage-Induced Hormetic Responses. Chapter in book: The Science of Hormesis in Health and Longevity, Rattan SIS, Kyriazi M (Editor). Academic Press
Mägdefrau AS, Ludwig K, Weigel C, Köse N, Guerra GM, Dakhovnik A, Kosan C
(Siehe online unter https://doi.org/10.1016/B978-0-12-814253-0.00013-9) - (2018) Epigenetics: Important aspects for anesthesiologists, pain and intensive care physicians. Anaesthesist. 67: 246-254
Reinhold AK, Jentho E, Schäfer ST, Bauer M, Rittner H
(Siehe online unter https://doi.org/10.1007/s00101-018-0424-7) - (2018) Metabolic stress - signaling and metabolic adaptation, Chapter in book: The Science of Hormesis in Health and Longevity, Rattan SIS, Kyriazi M (Editor). Academic Press
Balakrishnan P, Liebe T, Amro E, Dhaka L, Heinzel T, Heller R
(Siehe online unter https://doi.org/10.1016/B978-0-12-814253-0.00012-7) - (2018) Metabolic stress - signaling and metabolic adaptation, Chapter in book: The Science of Hormesis in Health and Longevity, Rattan SIS, Kyriazi M (Editor). Academic Press
Balakrishnan P, Liebe T, Amro E, Dhaka L, Heinzel T, Heller R
(Siehe online unter https://doi.org/10.1016/B978-0-12-814253-0.00012-7) - (2018) Metabolic stress - signaling and metabolic adaptation, Chapter in book: The Science of Hormesis in Health and Longevity, Rattan SIS, Kyriazi M (Editor). Academic Press
Balakrishnan P, Liebe T, Amro E, Dhaka L, Heinzel T, Heller R
(Siehe online unter https://doi.org/10.1016/B978-0-12-814253-0.00012-7) - (2018) Neuronal Stress and Its Hormetic Aspects, Chapter in book: The Science of Hormesis in Health and Longevity, Rattan SIS, Kyriazi M (Editor). Academic Press
Hofbrucker-MacKenzie SA, Sivaprakasam I, Ji Y, Kessels MM, Qualmann B
(Siehe online unter https://doi.org/10.1016/B978-0-12-814253-0.00015-2) - (2018) Pathogen-induced hormetic responses, Chapter in book: The Science of Hormesis in Health and Longevity, Rattan SIS, Kyriazi M (Editor). Academic Press
Jentho E, Lajqi T, Yang K, Winkler R, Stojiljkovic M, Wetzker R, Bauer M
(Siehe online unter https://doi.org/10.1016/B978-0-12-814253-0.00014-0) - (2018) Pathogen-induced hormetic responses, Chapter in book: The Science of Hormesis in Health and Longevity, Rattan SIS, Kyriazi M (Editor). Academic Press
Jentho E, Lajqi T, Yang K, Winkler R, Stojiljkovic M, Wetzker R, Bauer M
(Siehe online unter https://doi.org/10.1016/B978-0-12-814253-0.00014-0) - (2018) Pathogen-induced hormetic responses, Chapter in book: The Science of Hormesis in Health and Longevity, Rattan SIS, Kyriazi M (Editor). Academic Press
Jentho E, Lajqi T, Yang K, Winkler R, Stojiljkovic M, Wetzker R, Bauer M
(Siehe online unter https://doi.org/10.1016/B978-0-12-814253-0.00014-0) - (2018) Potential influence of sphingosine-1-phosphate signaling on HCMV replication in human embryonal lung fibroblasts. Med Microbiol Immunol. 207: 227-242
Zilch A, Rien C, Weigel C, Spengler K, Sauerbrei A, Heller R, Gräler M, Henke A
(Siehe online unter https://doi.org/10.1007/s00430-018-0543-4) - (2018) The sirtuin 1/2 inhibitor tenovin-1 induces a nonlinear apoptosis-inducing factordependent cell death in a p53 null Ewing's sarcoma cell line. Invest New Drugs. 36: 396-406
Marx C, Marx-Blümel L, Lindig N, Thierbach R, Hoelzer D, Becker S, Wittig S, Lehmann R, Slevogt H, Heinzel T, Wang ZQ, Beck JF, Sonnemann J
(Siehe online unter https://doi.org/10.1007/s10637-017-0541-1) - (2019) Age effect on thyroid hormone brain response in male mice. Endocrine. 66: 596-606
Kerp H, Engels K, Kramer F, Doycheva D, Sebastian Hönes G, Zwanziger D, Christian Moeller L, Heuer H, Führer D
(Siehe online unter https://doi.org/10.1007/s12020-019-02078-6) - (2019) Azithromycin does not improve disease severity in acute experimental pancreatitis. PLoS One. 14: e0216614
Weis S, Heindl M, Carvalho T, Jentho E, Lorenz J, Sommerer I, Mössner J, Hoffmeister A
(Siehe online unter https://doi.org/10.1371/journal.pone.0216614) - (2019) Cohesin-mediated NF-κB signaling limits hematopoietic stem cell self-renewal in aging and inflammation. J Exp Med. 216: 152-75
Chen Z, Amro EM, Becker F, Hölzer M, Rasa SMM, Njeru SN, Han B, Di Sanzo S, Chen Y, Tang D, Tao S, Harold R, Groth M, Romanov VS, Kirkpatrick JM, Kraus JM, Kestler HA, Marz M, Ori A, Neri F, Morita Y, Rudolph KL
(Siehe online unter https://doi.org/10.1084/jem.20181505) - (2019) Heme Induces Innate Immune Memory. BioRxiv
Jentho E, Novakovic B, Ruiz-Moreno C, Kourtzelis I, Martins R, Chavakis T, Soares MP, Kalafati L, Guerra J, Roestel F,Bohm P, Godmann M, Grinenko T, Eugster A, Beretta M, Joosten LAB, Netea MG, Stunnenberg HG, Bauer M, Weis S
(Siehe online unter https://doi.org/10.1101/2019.12.12.874578) - (2019) Memory-like inflammatory responses of microglia to rising doses of LPS: Key role of PI3Kγ. Front Immunol. 10: 2492
Lajqi T, Lang GP, Haas F, Williams DL, Hudalla H, Bauer M, Groth M, Wetzker R, Bauer R
(Siehe online unter https://doi.org/10.3389/fimmu.2019.02492) - (2019) Modulation of K+ channel N- type inactivation by sulfhydration through hydrogen sulfide and polysulfides. Pflugers Arch. 471: 557-571
Yang, K, Coburger I, Langner J, Peter N, Hoshi T, Schönherr R, Heinemann SH
(Siehe online unter https://doi.org/10.1007/s00424-018-2233-x) - (2019) Reduced ambient temperature exacerbates SIRS-induced cardiac autonomic dysregulation and myocardial dysfunction in mice. Basic Res Cardiol. 114: 26
Ndongson-Dongmo B, Lang GP, Mece O, Hechaichi N, Lajqi T, Hoyer D, Brodhun M, Heller R, Wetzker R, Franz M, Levy FO, Bauer R
(Siehe online unter https://doi.org/10.1007/s00395-019-0734-1) - (2019) The enigmatic function of PARP1: From PARylation activity to PAR readers. Cells. 8: 1625
Kamaletdinova TR, Fanaei-Kahrani Z, Wang ZQ
(Siehe online unter https://doi.org/10.3390/cells8121625) - (2019) The enigmatic function of PARP1: From PARylation activity to PAR readers. Cells. 8: 1625
Kamaletdinova TR, Fanaei-Kahrani Z, Wang ZQ
(Siehe online unter https://doi.org/10.3390/cells8121625) - (2019) The Na+/H+ exchanger Nhe1 modulates network excitability via GABA release. Cereb Cortex. 29: 4263-4276
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