Aufbau und Stabilisierung eines für die Tumorzellmigration notwendigen pH-Nanomilieus an der Zelloberfläche

• Antragsteller: Professor Dr. Christian Martin Stock
• Fachliche Zuordnung: Anatomie und Physiologie
• Förderung: Förderung von 2005 bis 2012
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 17814266

• Erstellungsjahr: 2012

Keine Zusammenfassung vorhanden

Projektbezogene Publikationen (Auswahl)

• Decorin and chondroitin-6 sulfate inhibit B16V melanoma cell migration and invasion by cellular acidification. Journal of Cellular Physiology, Vol. 226. 2011, Issue 10, pp. 2641-2650.
  Stock, Christian; Jungmann, Oliver & Seidler, Daniela G.
  
• Endothelial activation drives lateral migration and diapedesis of leukocytes. Cellular Immunology, Vol. 271. 2011, Issue 1, pp. 180-183.
  Stock, Christian & Riethmuller, Christoph
  
• Intracellular pH gradients in migrating cells. American Journal of Physiology-Cell Physiology, Vol. 300. 2011, Issue 3, pp. C490-C495.
  Martin, Christine; Pedersen, Stine F.; Schwab, Albrecht & Stock, Christian
  
• Is the multifunctional Na+/H+ exchanger isoform 1 a potential therapeutic target in cancer? Current Medicinal Chemistry, Vol. 19. 2012, Issue 5, pp. 647-660.
  Stock, C.; Ludwig, F.T. & Schwab, A.
  
• PDGFRα signaling in the primary cilium regulates NHE1-dependent fibroblast migration via coordinated differential activity of MEK1/2-ERK1/2-p90RSK and AKT signaling pathways. Journal of cell science, Vol. 126. 2013, pp. 953-965.
  Clement, Ditte L.; Mally, Sabine; Stock, Christian; Lethan, Mette; Satir, Peter; Schwab, Albrecht; Pedersen, Stine F. & Christensen, Søren T.
  
• Role of ion channels and transporters in cell Migration. Physiological Reviews, Vol. 92. 2012, No. 4, pp. 1865-1913.
  Schwab, Albrecht; Fabian, Anke; Hanley, Peter J. & Stock, Christian
  
• The Na+/H+ exchanger NHE1, but not the Na+, HCO3- cotransporter NBCn1, regulates motility of MCF7 breast cancer cells expressing constitutively Active ErbB2. Cancer Letters, Vol. 317. 2012, Issue 2, pp. 172-183.
  Lauritzen, Gitte; Stock, Christian-Martin; Lemaire, Justine; Lund, Stine F.; Jensen, Mie Frid; Damsgaard, Britt; Petersen, Katrine Seide; Wiwel, Maria; Rønnov-Jessen, Lone; Schwab, Albrecht & Pedersen, Stine Falsig
  
• High phosphate directly affects endothelial function by downregulating annexin II. Kidney International, Vol. 83. 2013, Issue 2, pp. 213-222.
  Di Marco, Giovana Seno; König, Maximilian; Stock, Christian; Wiesinger, Anne; Hillebrand, Uta; Reiermann, Stefanie; Reuter, Stefan; Amler, Susanne; Köhler, Gabriele; Buck, Friedrich; Fobker, Manfred; Kümpers, Philipp; Oberleithner, Hans; Hausberg, Martin; Lang, Detlef; Pavenstädt, Hermann & Brand, Marcus
  
• Roles of ion transport in control of cell motility. Comprehensive Physiology, Vol. 3. 2013, Issue 1, pp. 59‐119.
  Stock, Christian; Ludwig, Florian T.; Hanley, Peter J. & Schwab, Albrecht
  
• The Na+/H+-exchanger (NHE1) generates pH nanodomains at focal adhesions. Journal of Cellular Physiology, Vol. 228. 2013, Issue 6, pp. 1351-1358.
  Ludwig, Florian Timo; Schwab, Albrecht & Stock, Christian