Aufbau und Stabilisierung eines für die Tumorzellmigration notwendigen pH-Nanomilieus an der Zelloberfläche

• Applicant: Professor Dr. Christian Martin Stock
• Subject Area: Anatomy and Physiology
• Term: from 2005 to 2012
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 17814266

• Final Report Year: 2012

Final Report Abstract

No abstract available

Publications

• Decorin and chondroitin-6 sulfate inhibit B16V melanoma cell migration and invasion by cellular acidification. Journal of Cellular Physiology, Vol. 226. 2011, Issue 10, pp. 2641-2650.
  Christian Stock, Oliver Jungmann, Daniela G. Seidler
  (See online at https://doi.org/10.1002/jcp.22612)
• Endothelial activation drives lateral migration and diapedesis of leukocytes. Cellular Immunology, Vol. 271. 2011, Issue 1, pp. 180-183.
  Christian Stock, Christoph Riethmuller
  (See online at https://doi.org/10.1016/j.cellimm.2011.06.022)
• Intracellular pH gradients in migrating cells. American Journal of Physiology-Cell Physiology, Vol. 300. 2011, Issue 3, pp. C490-C495.
  Martin C., Pedersen S.F., Schwab A., Stock C.
  (See online at https://doi.org/10.1152/ajpcell.00280.2010)
• Is the multifunctional Na+/H+ exchanger isoform 1 a potential therapeutic target in cancer? Current Medicinal Chemistry, Vol. 19. 2012, Issue 5, pp. 647-660.
  C. Stock, F.T. Ludwig, A. Schwab
  (See online at https://doi.org/10.2174/092986712798992101)
• Role of ion channels and transporters in cell Migration. Physiological Reviews, Vol. 92. 2012, No. 4, pp. 1865-1913.
  Albrecht Schwab, Anke Fabian, Peter J. Hanley, Christian Stock
  (See online at https://doi.org/10.1152/physrev.00018.2011)
• The Na+/H+ exchanger NHE1, but not the Na+, HCO3- cotransporter NBCn1, regulates motility of MCF7 breast cancer cells expressing constitutively Active ErbB2. Cancer Letters, Vol. 317. 2012, Issue 2, pp. 172-183.
  Gitte Lauritzen, Christian-Martin Stock, Justine Lemaire, Stine F. Lund, et al.
  (See online at https://doi.org/10.1016/j.canlet.2011.11.023)
• High phosphate directly affects endothelial function by downregulating annexin II. Kidney International, Vol. 83. 2013, Issue 2, pp. 213-222.
  Giovana Seno Di Marco, Maximilian König, Christian Stock, Anne Wiesinger, Uta Hillebrand, et al.
  (See online at https://doi.org/10.1038/ki.2012.300)
• PDGFRα signaling in the primary cilium regulates NHE1-dependent fibroblast migration via coordinated differential activity of MEK1/2-ERK1/2-p90RSK and AKT signaling pathways. Journal of cell science, Vol. 126. 2013, pp. 953-965.
  Ditte L. Clement, Sabine Mally, Christian Stock, Mette Lethan, Peter Satir, Albrecht Schwab, Stine F. Pedersen, Søren T. Christensen
  (See online at https://doi.org/10.1242/jcs.116426)
• Roles of ion transport in control of cell motility. Comprehensive Physiology, Vol. 3. 2013, Issue 1, pp. 59‐119.
  Christian Stock, Florian T. Ludwig, Peter J. Hanley, Albrecht Schwab
  (See online at https://doi.org/10.1002/cphy.c110056)
• The Na+/H+-exchanger (NHE1) generates pH nanodomains at focal adhesions. Journal of Cellular Physiology, Vol. 228. 2013, Issue 6, pp. 1351-1358.
  Florian Timo Ludwig, Albrecht Schwab and Christian Stock
  (See online at https://doi.org/10.1002/jcp.24293)