Mechanisms of regulation of stem cells in the adult brain (B09)

• Subject Area: Molecular Biology and Physiology of Neurons and Glial Cells
• Term: from 2010 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 122491522

Adult stem cells drive tissue homeostasis and repair. In the previous funding period, we pioneered single cell technologies and used mathematical modeling to gain insight into neuronal stem cell activation and differentiation. We studied the transcriptional and cellular programs governing stem cells in the hippocampus and initiated an analysis of the transcriptome and translatome of stem cells in the ventricular-subventricular zone (V-SVZ). In the third period, we will extend the molecular analysis of V-SVZ stem cells. This analysis and quantification of stem cells across time will be used to implement a mathematical modeling describing V-SVZ stem cell dynamics. Gained knowledge shall advance our understanding of stem cell biology across the mammalian brain and other solid tissues.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 873: Maintenance and Differentiation of Stem Cells in Development und Disease
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Project Head: Professorin Dr. Ana Martin-Villalba