Entwicklung von Pd-katalysierten Domino-Reaktionen zur Synthese von molekularen Schaltern und Naturstoffen vom Lignan-Typ des Linoxepins

• Applicant: Professor Dr. Lutz F. Tietze
• Subject Area: Organic Molecular Chemistry - Synthesis and Characterisation
• Term: from 2010 to 2014
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 179916383

• Final Report Year: 2015

No abstract available

Publications

• In-vitro and in-vivo activity of 1-hydroxy-2-alkyl-4(1H)quinolone derivatives against Toxoplasma gondii. Antimicrobial Agents and Chemotherapy, Vol. 54. 2010, Issue 1, pp. 517-521.
  Bajohr, Lara Liv; Ma, Ling; Platte, Christian; Liesenfeld, Oliver; Tietze, Lutz F.; Groß, Uwe & Bohne, Wolfgang
  
• Synthesis of Novel 1-Hydroxyquinolones with High Anti-Toxoplasma Activity. Heterocycles, Special issue, Vol 82. 2010, No. 1, pp. 377 - 396.
  F. Tietze, Lutz & Ma, Ling
  
• Spectroscopically Well-Characterized RGD Optical Probe as a Prerequisite for Lifetime-Gated Tumor Imaging. Molecular Imaging, Vol. 10. 2011, issue: 6, pp. 469-480.
  Mathejczyk, Julia Eva; Pauli, Jutta; Dullin, Christian; Napp, Joanna; Tietze, Lutz-F.; Kessler, Horst; Resch-Genger, Ute & Alves, Frauke
  
• Synthesis and Biological Evaluation of Prodrugs Based on the Natural Antibiotic Duocarmycin for Use in ADEPT and PMT. Chemistry — A European Journal, Vol. 17. 2011, Issue 6, pp. 1922-1929.
  Tietze, Lutz F.; Schmuck, Kianga; Schuster, Heiko J.; Müller, Michael & Schuberth, Ingrid
  
• Approaches Targeting KV10.1 Open a Novel Window for Cancer Diagnosis and Therapy. Current Medicinal Chemistry, Vol. 19. 2012, Issue 5, pp. 675 - 682.
  Pardo, L.A.; Gomez-Varela, D.; Major, F.; Sansuk, K.; Leurs, R.; Downie, B.R.; Tietze, L.F. & Stuhmer, W.
  
• Domino Reactions in the Enantioselective Synthesis of Bioactive Natural Products. In: J. Cossy, S. Arseniyadis (Ed.), Modern Tools for the Synthesis of Complex Bioactive Molecules. John Wiley & Sons, 2012, p. 271-334, ISBN-13: 978-0470616185.
  Tietze, Lutz F.; Stewart, Scott G. & Düfert, Alexander
  
• Photoactivatable Prodrugs of Highly Potent Duocarmycin Analogues for a Selective Cancer Therapy. Chemistry — A European Journal, Vol. 19. 2013, Issue 5, pp. 1726-1731.
  Tietze, Lutz F.; Müller, Michael; Duefert, Svenia‐C.; Schmuck, Kianga & Schuberth, Ingrid
  
• Selective Cancer Therapy by Extracellular Activation of a Highly Potent Glycosidic Duocarmycin Analogue. Molecular Pharmaceutics, Vol. 10. 2013, Issue 5, pp. 1773–1782.
  Chen, Kai-Chuan; Schmuck, Kianga; Tietze, Lutz F. & Roffler, Steve R.
  
• Enantioselective Total Synthesis of the Lignan (+)-Linoxepin. Chemistry — A European Journal, Vol. 20. 2014, Issue 51, pp. 17119-17124.
  Tietze, Lutz F.; Clerc, Jérôme; Biller, Simon; Duefert, Svenia‐C. & Bischoff, Matthias
  
• The Paecilin Puzzle - Enantioselective Synthesis of the Proposed Structures of Paecilin A and B. Heterocycles, Vol 88. 2014, No. 2, pp. 1101 - 1119.
  F. Tietze, Lutz; Ma, Ling; Jackenkroll, Stefan; R. Reiner, Johannes; Hierold, Judith; Gnanaprakasam, Boopathy & Heidemann, Sven
  
• An efficient Domino Sonogashira/double Carbopalladation/C-H-Activation Reaction leading to Fluorescent Polycyclic Aromatic Hydrocarbons. Heterocycles Vol 90. 2015, No. 2, pp. 919 - 927.
  F. Tietze, Lutz & Eichhorst, Christoph
  
• Vier‐ und sechsfache Tandem‐Dominoreaktionen zur Synthese von dimeren tetrasubstituierten Alkenen als molekulare Doppelschalter. Angewandte Chemie, Vol. 127. 2015, Issue 35, pp. 10457-10461.
  Tietze, Lutz F.; Waldecker, Bernd; Ganapathy, Dhandapani; Eichhorst, Christoph; Lenzer, Thomas; Oum, Kawon; Reichmann, Sven O. & Stalke, Dietmar