Insights into the cell biology and modulation of ADAM10 (A03)

• Subject Area: Biochemistry
• Term: from 2010 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 125440785

Animal models are used to study the physiologic function of ADAM10 in development, tissue physiology and disease. ADAM10 as a sheddase for Notch receptors and cadherins plays a role in leukocyte migration, axon targeting, glia function and in developmental processes. Intracellular trafficking, maturation and the half-life of ADAM10 and its regulation by the tetraspanin network will be studied. The project will provide new information how ADAM10 can be activated and how ADAM10-directed therapeutic approaches can be developed.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 877: Proteolysis as a Regulatory Event in Pathophysiology
• Applicant Institution: Christian-Albrechts-Universität zu Kiel
• Project Head: Professor Dr. Paul Saftig