Proteolysis in the regulation of non-apoptotic cell death (B02)

• Subject Area: Immunology
• Term: from 2010 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 125440785

The project studies proteolysis in the regulation of non-apoptotic cell death. The mitochondrial serine protease HtrA2/Omi is a component of TNFα-induced necroptosis. Furthermore, an unexpected contribution of ADAM17 in the induction of necroptosis was discovered, which will be further analyzed in the next funding period. The role of caspase-8 in necroptosis is different in human and murine cells since caspase-10, a homolog of caspase-8, is present in humans but not in mice, pointing to a species-specific role of caspase-8 in the regulation of necroptosis.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 877: Proteolysis as a Regulatory Event in Pathophysiology
• Applicant Institution: Christian-Albrechts-Universität zu Kiel
• Project Heads: Professor Dr. Dieter Adam; Professor Dr. Stefan Schütze, until 6/2014