Identifizierung und präklinische Evaluation von small molecules zur Hemmung von JAK2, einer durch die Punktmutation V617F konstitutionell aktivierten Tyrosinkinase, bei Patienten mit Polycythaemia vera, essentieller Thrombozythämie und Osteomyelofibrose

• Applicant: Professorin Dr. Claudia Scholl
• Subject Area: Hematology, Oncology
• Term: from 2005 to 2009
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 18283863

• Final Report Year: 2007

Final Report Abstract

No abstract available

Publications

• Cdx4 dysregulates Hox gene expression and generates acute myeloid leukemia alone and in cooperation with Meisla in a murine model. Proc Natl Acad Sci USA . 2006; 103(45): 16924-9
  Bansal D, Scholl C, Fröhling S, McDowell E, Lee BH, Döhner K, Ernst P, Davidson AJ, Daley GQ, Zon LI, Gilliland DG, Huntly BJ
  
• HOX gene regulation in acute myeloid leukemia: CDX marks the spot? Cell Cycle. 2007;6(18):2241-5
  Fröhling S, Scholl C, Bansal D, Huntly BJ
  
• The homeobox gene CDX2 is aberrantly expressed in most cases of acute myeloid leukemia and promotes leukemogenesis. J Clin Invest. 2007;117(4):1037-48
  Scholl C, Bansal D, Döhner K, Eiwen K, Huntly BJ, Lee BH, Rücker FG, Schlenk RF, Bullinger L, Döhner H, Gilliland DG, Fröhling S