How does the interaction of protein phosphatase 2A and small t antigen lead to activation of the PI3K pathway and subsequent transformation of primary human cells? Determination of the level of interaction and elucidation of the mechanism

• Antragstellerin: Dr. Tamara Utermark
• Fachliche Zuordnung: Zellbiologie
• Förderung: Förderung von 2005 bis 2008
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 18426927

• Erstellungsjahr: 2008

Zusammenfassung der Projektergebnisse

Keine Zusammenfassung vorhanden

Projektbezogene Publikationen (Auswahl)

• Back to the future - Polyoma middle T and PI3 kinase. Cancer Biology Seminars, September 22 2006, Boston MA
  Utermark T
  
• Requirement for PI3K Activation in Polyoma Middle T antigen Mediated Transformation of Human Cells. DNA Tumor Virus Meeting, July 11-15 2006, Salk Institute, La Jolla CA
  Utermark T, Jean J Zhao, Thomas M Roberts
  
• Targeted disruption of the PIK3CA gene blocks mammary tumorigenesis mediated by Polyoma middle Tantigen. Breast Cancer Research at Harvard. Fourth Annual Symposium of the Dana-Farber/Harvard Cancer Center Program in Breast Cancer. March 23 2007, Boston MA
  Utermark T, Hailing Cheng, Thomas M Roberts, Jean J Zhao
  
• The p110alpha isoform of phosphatidylinositol 3-kinase is essential for polyomavirus middle T antigen-mediated transformation. J Virol. 2007 Jul;81(13):7069-76. Epub 2007 Apr 18
  Utermark T, Schaffhausen BS, Roberts TM, Zhao JJ