How does the interaction of protein phosphatase 2A and small t antigen lead to activation of the PI3K pathway and subsequent transformation of primary human cells? Determination of the level of interaction and elucidation of the mechanism

Applicant Dr. Tamara Utermark

Subject Area Cell Biology

Term from 2005 to 2008

Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 18426927

Final Report Year 2008

Final Report Abstract

No abstract available

Back to the future - Polyoma middle T and PI3 kinase. Cancer Biology Seminars, September 22 2006, Boston MA
Utermark T
Requirement for PI3K Activation in Polyoma Middle T antigen Mediated Transformation of Human Cells. DNA Tumor Virus Meeting, July 11-15 2006, Salk Institute, La Jolla CA
Utermark T, Jean J Zhao, Thomas M Roberts
Targeted disruption of the PIK3CA gene blocks mammary tumorigenesis mediated by Polyoma middle Tantigen. Breast Cancer Research at Harvard. Fourth Annual Symposium of the Dana-Farber/Harvard Cancer Center Program in Breast Cancer. March 23 2007, Boston MA
Utermark T, Hailing Cheng, Thomas M Roberts, Jean J Zhao
The p110alpha isoform of phosphatidylinositol 3-kinase is essential for polyomavirus middle T antigen-mediated transformation. J Virol. 2007 Jul;81(13):7069-76. Epub 2007 Apr 18
Utermark T, Schaffhausen BS, Roberts TM, Zhao JJ