Molecular mechanisms and complex formation in the cytoplasmic mRNA quality control (A11)

• Subject Area: Biochemistry
• Term: from 2010 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 105286809

In this project we will investigate the mechanisms of the cytoplasmic mRNA quality control systems. We have identified the DEAD-box RNA helicase Dbp5 and the nuclear guard-proteins Gbp2 and Hrb1 to be novel players in these cytoplasmic quality control pathways. This project aims to characterize their function in these processes by analysis of their in vivo complex formations in different mutants of the model organism Saccharomyces cerevisiae.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 860: Integrative Structural Biology of Dynamic Macromolecular Assemblies
• Applicant Institution: Georg-August-Universität Göttingen
• Project Head: Professorin Dr. Heike Krebber