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Influence of post-translational modifications on the biology of linker histone HIS-24 in Caenorhabditis elegans

Subject Area General Genetics and Functional Genome Biology
Term from 2006 to 2012
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 19228257
 
Final Report Year 2012

Final Report Abstract

The structural and functional roles of the linker histone H1 remain enigmatic. The earlier concepts of H1 as a general repressor have to be re-evaluated in the light of our and others experiments demonstrating a minor effect of H1 deletion in unicellular organisms. Within our study on linker histone proteins in C. elegans we provide new insights into the biology of H1 and its post-translational modifications. We show that the function of linker histone may be evolutionarily conserved and H1 and heterochromatin protein HP1 do not have a general function such as participation in the basic structural unit of the chromatin, but instead can contribute to specific programs of innate immune response or Hox gene regulation. Our data suggest a common and dual role for C. elegans H1 and HP1, functioning both as chromatin architectural proteins and at the same time as modifiers of a small subset of genes. Furthermore, we provide the first direct evidence for redundant functions of H1 and HP1 in metazoan development.

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