Physiological functions of novel STIM1 and STIM2 splice variants (A02)

• Subject Area: Molecular Biology and Physiology of Neurons and Glial Cells
• Term: from 2011 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 157660137

Store-operated calcium entry (SOCE) is a ubiquitous mechanism regulating Ca2+ homeostasis. Functional and active Ca2+ release-activated Ca2+ (CRAC) channels are composed of a complex of the pore-forming Orai (Orai1-3) subunits within the plasma membrane in close apposition to their ER-localized activators STIM1 and STIM2. We want to understand how individual cell-types tune SOCE to suit the spatial and temporal requirements of particular functions by splicing the activator molecules STIM1 and STIM2.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 894: Ca2+-Signalling: Molecular Mechanisms and Integrative Functions
• Applicant Institution: Universität des Saarlandes
• Project Head: Professorin Barbara Anne Niemeyer, Ph.D.