CAPS function in dorsal root ganglion neurons (A09)

• Subject Area: Molecular Biology and Physiology of Neurons and Glial Cells
• Term: from 2011 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 157660137

Recently we showed that the priming factor CAPS1 supports synaptic transmission of dorsal root ganglion (DRG) neurons while its paralog CAPS2 promotes the release of neuropeptides at their somata. These functions of both CAPS paralogs are based on their different subcellular localizations. In the next funding period we will: 1. Investigate the underlying molecular mechanism of CAPS1 and CAPS2 localization in DRG neurons; 2. Determine the difference of CAPS-dependent neuropeptide release between soma and synapses; 3. Investigate the role of CAPS2 in the development of neuropathic pain in animals.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 894: Ca2+-Signalling: Molecular Mechanisms and Integrative Functions
• Applicant Institution: Universität des Saarlandes
• Project Head: Privatdozentin Dr. Ute Becherer, Ph.D.