Detailing the relation between T2* and tissue pO2 with MR-PHYSIOL to enable unambiguous MR characterization of renal hemodynamics and oxygenation
Nephrology
Final Report Abstract
To be rendered a quantitative physiological approach, parametric MRI was calibrated with established quantitative physiological measurements. These efforts culminated in the proposal of MR oximetry as a multi-faceted MRI protocol to compliment quantitative physiological measurements and NIRS. This hybrid multi-modality approach offers an in vivo tool for better insight into renal perfusion and oxygenation. This novel instrument was put to good use to demonstrate that renal tissue hypoxia has a pivotal role in AKI. Once available to the clinicians, multiparametric renal MR oximetry would represent the first non-invasive method to reliably measure renal blood oxygenation. It could be combined with MR techniques for perfusion and diffusion (to probe tubular volume fraction) en route to a comprehensive characterization of renal haemodynamics and tissue oxygenation, which may be an important biomarker for the early stages of a range of kidney diseases.
Publications
- Advancing Cardiovascular, Neurovascular, and Renal Magnetic Resonance Imaging in Small Rodents Using Cryogenic Radiofrequency Coil Technology. Front Pharmacol 6: 255, 2015
Niendorf T, Pohlmann A, Reimann HM, Waiczies H, Peper E, Huelnhagen T, Seeliger E, Schreiber A, Kettritz R, Strobel K, Ku MC, Waiczies S
(See online at https://doi.org/10.3389/fphar.2015.00255) - Detailing renal hemodynamics and oxygenation in rats by a combined near-infrared spectroscopy and invasive probe approach. Biomed Opt Express 6(2): 309-323, 2015
Grosenick D, Cantow K, Arakelyan K, Wabnitz H, Flemming B, Skalweit A, Ladwig M, Macdonald R, Niendorf T, Seeliger E
(See online at https://doi.org/10.1364/BOE.6.000309) - How bold is blood oxygenation level-dependent (BOLD) magnetic resonance imaging of the kidney? Opportunities, challenges and future directions. Acta Physiol (Oxf) 213(1): 19-38, 2015
Niendorf T, Pohlmann A, Arakelyan K, Flemming B, Cantow K, Hentschel J, Grosenick D, Ladwig M, Reimann H, Klix S, Waiczies S, Seeliger E
(See online at https://doi.org/10.1111/apha.12393) - Acute effects of ferumoxytol on regulation of renal hemodynamics and oxygenation. Sci Rep 6: 29965, 2016
Cantow K, Pohlmann A, Flemming B, Ferrara F, Waiczies S, Grosenick D, Niendorf T, Seeliger E
(See online at https://doi.org/10.1038/srep29965) - Assessment of Renal Hemodynamics and Oxygenation by Simultaneous Magnetic Resonance Imaging (MRI) and Quantitative Invasive Physiological Measurements. Methods Mol Biol 1397: 129-154, 2016
Cantow K, Arakelyan K, Seeliger E, Niendorf T, Pohlmann A
(See online at https://doi.org/10.1007/978-1-4939-3353-2_11) - Magnetic Resonance Imaging (MRI) Analysis of Ischemia/Reperfusion in Experimental Acute Renal Injury. Methods Mol Biol 1397: 113-127, 2016
Pohlmann A, Arakelyan K, Seeliger E, Niendorf T
(See online at https://doi.org/10.1007/978-1-4939-3353-2_10) - What Do BOLD MR Imaging Changes in Donors' Remaining Kidneys Tell Us? Radiology 281(2): 653-655, 2016
Niendorf T, Flemming B, Evans RG, Seeliger E
(See online at https://doi.org/10.1148/radiol.2016160411) - Experimental MRI Monitoring of Renal Blood Volume Fraction Variations En Route to Renal Magnetic Resonance Oximetry. Tomography 3(4): 188-200, 2017
Pohlmann A, Cantow K, Huelnhagen T, Grosenick D, Dos Santos Periquito J, Boehmert L, Gladytz T, Waiczies S, Flemming B, Seeliger E, Niendorf T
(See online at https://doi.org/10.18383/j.tom.2017.00012) - Interpretation of functional renal MRI findings: Where physiology and imaging sciences need to talk across domains. J Magn Reson Imaging 47(4): 1140-1141, 2018
Brix S, Cantow K, Flemming B, Pohlmann A, Niendorf T, Seeliger E
(See online at https://doi.org/10.1002/jmri.25829)
