The molecular anatomy of synaptic vesicle recycling at the hair cell ribbon synapse (A05+)

• Subject Area: Molecular Biology and Physiology of Neurons and Glial Cells
• Term: from 2011 to 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 154113120

A05 proposes to use several molecular and metabolic imaging tools that we have recently developed, including nanoscale secondary ion mass spectrometry (nanoSIMS) and 10X expansion microscopy (X10), to measure protein turnover in inner hair cells (IHCs). This should enable us to suggest if sensory regimes promote IHC turnover and “rejuvenation”, which may have important consequences in hearing disorders linked to IHC degeneration.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 889: Cellular Mechanisms of Sensory Processing
• Applicant Institution: Georg-August-Universität Göttingen
• Project Heads: Professor Dr. Tobias Moser, until 12/2014; Professor Silvio-Olivier Rizzoli, Ph.D.