EXC 1003:  Cells in Motion - CiM: Visualisierung und Verstehen zellulären Verhaltens in lebenden Organismen

• Fachliche Zuordnung: Grundlagen der Biologie und Medizin
• Förderung: Förderung von 2012 bis 2019
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 194347757

• Erstellungsjahr: 2019

Zusammenfassung der Projektergebnisse

Zellen sind die Grundbausteine aller Organismen und die Untersuchung zellulärer Plastizität und Dynamik ist elementar für das Verständnis von Entwicklung, Homöostase und Regeneration. Neuartige optische Bildgebungsstrategien, die dynamisches Zellverhalten in vivo darstellen, haben unser Wissen revolutioniert und eindrücklich die Notwendigkeit der Untersuchung zellulären Verhaltens in lebenden Organismen untermauert. In diesem Themenbereich hat der Exzellenzcluster ‘Cells in Motion – CiM‘ in den letzten Jahren einen national und international sichtbaren Forschungsschwerpunkt aufgebaut. Basierend auf der interfakultären Expertise in Münster hat unsere Forschung dazu beigetragen, Limitationen im Bereich der optischen und medizinischen Bildgebung zu überwinden und das Zellverhalten im Organismus durch Entwicklung und Anwendung neuartiger Bildgebungsstrategien besser zu verstehen. Unsere Vision bleibt unverändert die Schaffung eines interfakultären Umfelds, das die biomedizinische Grundlagenforschung, die klinische Translation sowie deren Interaktion nachhaltig befördert. Hierbei ist die Bildgebung verbindende Strategie zur Charakterisierung des Zellverhaltens, gleichgültig ob in Einzelzellen oder Geweben, in Tiermodellen oder Patienten. Um traditionelle Fakultätsgrenzen zu überwinden und den wissenschaftlichen Austausch zu fördern, wurden sieben neue interdisziplinäre Professuren und zwei neue klinisch-translationale Professuren eingerichtet, sowie das interfakultäre Cells in Motion Interfaculty Centre (CiMIC) gegründet. CiMIC verstetigt mit finanzieller Unterstützung der WWU das Konzept des Exzellenzclusters und wird zukünftig im Forschungsneubau Multiscale Imaging Centre – MIC verortet sein. Ein weiteres wichtiges Element unseres Konzepts ist eine neue interfakultäre Ausbildungsstruktur, die Gleichstellungsaspekte auf allen Ebenen integriert (Careers in Motion Centre) und Medizinern durch einen Master in ‘Experimental Medicine‘ erstmals den Zugang zu einem PhD-Programm ermöglicht. CiM bündelt erfolgreich die Exzellenzbereiche ‘Zellbiologie‘ und ‘Molekulare Bildgebung‘ der WWU und integriert kompetitiv geförderte interdisziplinäre Netzwerke zwischen den Fakultäten für Medizin, Naturwissenschaften und Mathematik sowie dem Max-Planck-Institut für Molekulare Biomedizin. Durch den Aufbau eines interaktiven und langfristigen Forschungs- und Ausbildungsnetzwerks zwischen den beteiligten Fakultäten hat CiM nachhaltige strukturelle Änderungen an der WWU bewirkt und die nationale und internationale Sichtbarkeit der WWU im Bereich der Lebens- und Naturwissenschaften signifikant erhöht. Unser Ziel ist es nun, mit der Unterstützung durch CiMIC und durch die Einrichtung von neuen Sonderforschungsbereichen und Forschungsnetzwerken die erfolgreiche Arbeit im Bereich der Anwendung innovativer Bildgebungstechnologien in der biomedizinischen Forschung, in Diagnostik und Therapie weiterzuführen.

Link zum Abschlussbericht

https://doi.org/10.2314/KXP:170112324X

Projektbezogene Publikationen (Auswahl)

• Bacteria tracking by in vivo magnetic resonance imaging. BMC Biol. 2013; 11: 63
  Hoerr, Verena; Tuchscherr, Lorena; Hüve, Jana; Nippe, Nadine; Loser, Karin; Glyvuk, Nataliya; Tsytsyura, Yaroslav; Holtkamp, Michael; Sunderkötter, Cord; Karst, Uwe; Klingauf, Jürgen; Peters, Georg; Löffler, Bettina & Faber, Cornelius
  
• Blocking endocytosis enhances short-term synaptic depression under conditions of normal availability of vesicles. Neuron. 2013; 80: 343-349
  Hua, Yunfeng; Woehler, Andrew; Kahms, Martin; Haucke, Volker; Neher, Erwin & Klingauf, Jürgen
  
• cAMP-induced secretion of endothelial von Willebrand factor is regulated by a phosphorylation/dephosphorylation switch in annexin A2. Blood. 2013; 122: 1042-1051
  Brandherm, Ines; Disse, Jennifer; Zeuschner, Dagmar & Gerke, Volker
  
• Endothelial TWIK-related potassium channel-1 (TREK1) regulates immune-cell trafficking into the CNS. Nat Med. 2013; 19: 1161-1165
  Bittner, Stefan; Ruck, Tobias; Schuhmann, Michael K.; Herrmann, Alexander M.; Maati, Hamid Moha Ou; Bobak, Nicole; Göbel, Kerstin; Langhauser, Friederike; Stegner, David; Ehling, Petra; Borsotto, Marc; Pape, Hans-Christian; Nieswandt, Bernhard; Kleinschni
  
• FIM, a novel FTIR-based imaging method for high throughput locomotion analysis. PLoS One. 2013; 8: e53963
  Risse, Benjamin; Thomas, Silke; Otto, Nils; Löpmeier, Tim; Valkov, Dimitar; Jiang, Xiaoyi & Klämbt, Christian
  
• Alarmin S100A8/S100A9 as a biomarker for molecular imaging of local inflammatory activity. Nat Commun. 2014; 5: 4593
  Vogl, Thomas; Eisenblätter, Michel; Völler, Tom; Zenker, Stefanie; Hermann, Sven; van Lent, Peter; Faust, Andreas; Geyer, Christiane; Petersen, Beatrix; Roebrock, Kirsten; Schäfers, Michael; Bremer, Christoph & Roth, Johannes
  
• Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone. Nature. 2014; 507: 323-328
  Kusumbe, Anjali P.; Ramasamy, Saravana K. & Adams, Ralf H.
  
• Differential phospholipase C-dependent modulation of TASK and TREK two-pore domain K+ channels in rat thalamocortical relay neurons. J Physiol. 2015; 593: 127-144
  Bista, Pawan; Pawlowski, Matthias; Cerina, Manuela; Ehling, Petra; Leist, Michael; Meuth, Patrick; Aissaoui, Ania; Borsotto, Marc; Heurteaux, Catherine; Decher, Niels; Pape, Hans‐Christian; Oliver, Dominik; Meuth, Sven G. & Budde, Thomas
  
• Ena/VASP Proteins Cooperate with the WAVE Complex to Regulate the Actin Cytoskeleton. Dev Cell. 2014; 30: 569-584
  Chen, Xing Judy; Squarr, Anna Julia; Stephan, Raiko; Chen, Baoyu; Higgins, Theresa E.; Barry, David J.; Martin, Morag C.; Rosen, Michael K.; Bogdan, Sven & Way, Michael
  
• Endothelial Notch activity promotes angiogenesis and osteogenesis in bone. Nature. 2014; 507: 376-380
  Ramasamy, Saravana K.; Kusumbe, Anjali P.; Wang, Lin & Adams, Ralf H.
  
• Fusing VE-Cadherin to alpha-Catenin Impairs Fetal Liver Hematopoiesis and Lymph but Not Blood Vessel Formation. Mol Cell Biol. 2014; 34: 1634-1648
  Dartsch, Nina; Schulte, Dörte; Hägerling, René; Kiefer, Friedemann & Vestweber, Dietmar
  
• Large Scale RNAi Reveals the Requirement of Nuclear Envelope Breakdown for Nuclear Import of Human Papillomaviruses. PLoS Pathog. 2014; 10: e1004162
  Aydin, Inci; Weber, Susanne; Snijder, Berend; Samperio Ventayol, Pilar; Kühbacher, Andreas; Becker, Miriam; Day, Patricia M.; Schiller, John T.; Kann, Michael; Pelkmans, Lucas; Helenius, Ari & Schelhaas, Mario
  
• Leukocyte extravasation and vascular permeability are each controlled in vivo by different tyrosine residues of VE-cadherin. Nat Immunol. 2014; 15: 223-230
  Wessel, Florian; Winderlich, Mark; Holm, Maren; Frye, Maike; Rivera-Galdos, Ronmy; Vockel, Matthias; Linnepe, Ruth; Ipe, Ute; Stadtmann, Anika; Zarbock, Alexander; Nottebaum, Astrid F & Vestweber, Dietmar
  
• Serial F-18-FDG PET/CT distinguishes inflamed from stable plaque phenotypes in shear-stress induced murine atherosclerosis. Atherosclerosis. 2014; 234: 276-282
  Wenning, Christian; Kloth, Christopher; Kuhlmann, Michael T.; Jacobs, Andreas H.; Schober, Otmar; Hermann, Sven & Schäfers, Michael A.
  
• The Drosophila FHOD1-like formin Knittrig acts through Rok to promote stress fiber formation and directed macrophage migration during the cellular immune response. Development. 2014; 141: 1366-1380
  Lammel, Uwe; Bechtold, Meike; Risse, Benjamin; Berh, Dimitri; Fleige, Astrid; Bunse, Ingrid; Jiang, Xiaoyi; Klämbt, Christian & Bogdan, Sven
  
• Total variation regularization in measurement and image space for PET reconstruction. Inverse Probl. 2014; 30: 105003
  Burger, M.; Müller, J.; Papoutsellis, E. & Schönlieb, C. B.
  
• Ultraviolet B light attenuates the systemic immune response in central nervous system autoimmunity. Ann Neurol. 2014; 75: 739-758
  Breuer, Johanna; Schwab, Nicholas; Schneider‐Hohendorf, Tilman; Marziniak, Martin; Mohan, Hema; Bhatia, Urvashi; Gross, Catharina C.; Clausen, Björn E.; Weishaupt, Carsten; Luger, Thomas A.; Meuth, Sven G.; Loser, Karin & Wiendl, Heinz
  
• Viral suppressors of the RIG-I-mediated interferon response are pre-packaged in influenza virions. Nat Commun. 2014; 5: 5645
  Liedmann, Swantje; Hrincius, Eike R.; Guy, Cliff; Anhlan, Darisuren; Dierkes, Rüdiger; Carter, Robert; Wu, Gang; Staeheli, Peter; Green, Douglas R.; Wolff, Thorsten; McCullers, Jonathan A.; Ludwig, Stephan & Ehrhardt, Christina
  
• VLA-4 blockade promotes differential routes into human CNS involving PSGL-1 rolling of T cells and MCAM- adhesion of TH17 cells. J Exp Med. 2014; 211: 1833-1846
  Schneider-Hohendorf, Tilman; Rossaint, Jan; Mohan, Hema; Böning, Daniel; Breuer, Johanna; Kuhlmann, Tanja; Gross, Catharina C.; Flanagan, Ken; Sorokin, Lydia; Vestweber, Dietmar; Zarbock, Alexander; Schwab, Nicholas & Wiendl, Heinz
  
• A Bio-Inspired, Catalytic E --> Z Isomerization of Activated Olefins. J Am Chem Soc. 2015; 137: 11254-11257
  Metternich, Jan B. & Gilmour, Ryan
  
• A Dynamic Unfolded Protein Response Contributes to the Control of Cortical Neurogenesis. Developmental Cell. 2015; 35: 553-567
  Laguesse, Sophie; Creppe, Catherine; Nedialkova, Danny D.; Prévot, Pierre-Paul; Borgs, Laurence; Huysseune, Sandra; Franco, Bénédicte; Duysens, Guérin; Krusy, Nathalie; Lee, Gabsang; Thelen, Nicolas; Thiry, Marc; Close, Pierre; Chariot, Alain; Malgrange, Brigitte; Leidel, Sebastian A.; Godin, Juliette D. & Nguyen, Laurent
  
• A novel family of fluorescent hypoxia sensors reveal strong heterogeneity in tumor hypoxia at the cellular level. Embo J. 2016; 35: 102-113
  Erapaneedi, Raghu; Belousov, Vsevolod V; Schäfers, Michael & Kiefer, Friedemann
  
• Blocking neutrophil diapedesis prevents hemorrhage during thrombocytopenia. J Exp Med. 2015; 212: 1255-1266
  Hillgruber, Carina; Pöppelmann, Birgit; Weishaupt, Carsten; Steingräber, Annika Kathrin; Wessel, Florian; Berdel, Wolfgang E.; Gessner, J. Engelbert; Ho-Tin-Noé, Benoît; Vestweber, Dietmar & Goerge, Tobias
  
• CD8+ T cell-mediated neuronal dysfunction and degeneration in limbic encephalitis. Front Neurol. 2015; 6: 163
  Ehling, Petra; Melzer, Nico; Budde, Thomas & Meuth, Sven G.
  
• Focal MMP-2 and MMP-9 Activity at the Blood-Brain Barrier Promotes Chemokine-Induced Leukocyte Migration. Cell Rep. 2015; 10: 1040-1054
  Song, Jian; Wu, Chuan; Korpos, Eva; Zhang, Xueli; Agrawal, Smriti M.; Wang, Ying; Faber, Cornelius; Schäfers, Michael; Körner, Heinrich; Opdenakker, Ghislain; Hallmann, Rupert & Sorokin, Lydia
  
• Influence of cell shape, inhomogeneities and diffusion barriers in cell polarization models. Phys Biol. 2015; 12: 066014
  Giese, Wolfgang; Eigel, Martin; Westerheide, Sebastian; Engwer, Christian & Klipp, Edda
  
• Interfering with VE-PTP stabilizes endothelial junctions in vivo via Tie-2 in the absence of VE-cadherin. J Exp Med. 2015; 212: 2267-2287
  Frye, Maike; Dierkes, Martina; Küppers, Verena; Vockel, Matthias; Tomm, Janina; Zeuschner, Dagmar; Rossaint, Jan; Zarbock, Alexander; Koh, Gou Young; Peters, Kevin; Nottebaum, Astrid Fee & Vestweber, Dietmar
  
• JAM-A regulates cortical dynein localization through Cdc42 to control planar spindle orientation during mitosis. Nat Commun. 2015; 6: 8128
  Tuncay, Hüseyin; Brinkmann, Benjamin F.; Steinbacher, Tim; Schürmann, Annika; Gerke, Volker; Iden, Sandra & Ebnet, Klaus
  
• Multimodal imaging reveals temporal and spatial microglia and matrix metalloproteinase activity after experimental stroke. J Cereb Blood Flow Metab.2015; 35: 1711-1721
  Zinnhardt, Bastian; Viel, Thomas; Wachsmuth, Lydia; Vrachimis, Alexis; Wagner, Stefan; Breyholz, Hans-Jörg; Faust, Andreas; Hermann, Sven; Kopka, Klaus; Faber, Cornelius; Dollé, Frédéric; Pappata, Sabina; Planas, Anna M.; Tavitian, Bertrand; Schäfers, Mic
  
• Optimization of Codon Translation Rates via tRNA Modifications Maintains Proteome Integrity. Cell. 2015; 161: 1606-1618
  Nedialkova, Danny D. & Leidel, Sebastian A.
  
• Puzzle Approach to Pose Tracking of a Rigid Object in a Multi Camera System. Lect Notes Comput Sc. 2015; 9256: 337-349
  Schmid, Sönke; Jiang, Xiaoyi & Schäfers, Klaus
  
• The motorized RhoGAP myosin IXb (Myo9b) in leukocytes regulates experimental autoimmune encephalomyelitis induction and recovery. J Neuroimmunol. 2015; 282: 25-32
  Liu, Zhijun; Xu, Yan; Zhang, Xueli; Song, Jian; Sorokin, Lydia & Bähler, Martin
  
• The Triple-Repeat Protein Anakonda Controls Epithelial Tricellular Junction Formation in Drosophila. Dev Cell. 2015; 33: 535-548
  Byri, Sunitha; Misra, Tvisha; Syed, Zulfeqhar A.; Bätz, Tilmann; Shah, Jimit; Boril, Lukas; Glashauser, Jade; Aegerter-Wilmsen, Tinri; Matzat, Till; Moussian, Bernard; Uv, Anne & Luschnig, Stefan
  
• Age-dependent modulation of vascular niches for haematopoietic stem cells. Nature. 2016; 532: 380-384
  Kusumbe, Anjali P.; Ramasamy, Saravana K.; Itkin, Tomer; Mäe, Maarja Andaloussi; Langen, Urs H.; Betsholtz, Christer; Lapidot, Tsvee & Adams, Ralf H.
  
• Cannabinoid Receptor 2 Modulates Susceptibility to Experimental Cerebral Malaria through a CCL17-dependent Mechanism. J Biol Chem. 2016; 291: 19517-19531
  Alferink, Judith; Specht, Sabine; Arends, Hannah; Schumak, Beatrix; Schmidt, Kim; Ruland, Christina; Lundt, Ramona; Kemter, Andrea; Dlugos, Andrea; Kuepper, Janina M.; Poppensieker, Karola; Findeiss, Matthias; Albayram, Önder; Otte, David-M.; Marazzi, Janine; Gertsch, Jürg; Förster, Irmgard; Maier, Wolfgang; Scheu, Stefanie; ... & Zimmer, Andreas
  
• Changing POU dimerization preferences converts Oct6 into a pluripotency inducer. EMBO Rep. 2017; 18: 319-333
  Jerabek, Stepan; Ng, Calista KL; Wu, Guangming; Arauzo‐Bravo, Marcos J; Kim, Kee‐Pyo; Esch, Daniel; Malik, Vikas; Chen, Yanpu; Velychko, Sergiy; MacCarthy, Caitlin M; Yang, Xiaoxiao; Cojocaru, Vlad; Schöler, Hans R & Jauch, Ralf
  
• Combinatorial effects of doxorubicin and retargeted tissue factor by intratumoral entrapment of doxorubicin and proapoptotic increase of tumor vascular infarction. Oncotarget. 2016; 7: 82458-82472
  Stucke-Ring, Janine; Ronnacker, Julian; Brand, Caroline; Höltke, Carsten; Schliemann, Christoph; Kessler, Torsten; Schmidt, Lars Henning; Harrach, Saliha; Mantke, Verena; Hintelmann, Heike; Hartmann, Wolfgang; Wardelmann, Eva; Lenz, Georg; Wünsch, Bernhard; Müller-Tidow, Carsten; Mesters, Rolf M.; Schwöppe, Christian & Berdel, Wolfgang E.
  
• Directed transport of neutrophil-derived extracellular vesicles enables platelet-mediated innate immune response. Nat Commun. 2016; 7: 13464
  Rossaint, Jan; Kühne, Katharina; Skupski, Jennifer; Van Aken, Hugo; Looney, Mark R.; Hidalgo, Andres & Zarbock, Alexander
  
• Endothelial basement membrane laminin 511 is essential for shear stress response. EMBO J. 2017; 36: 183-201
  Di Russo, Jacopo; Luik, Anna‐Liisa; Yousif, Lema; Budny, Sigmund; Oberleithner, Hans; Hofschröer, Verena; Klingauf, Juergen; Van Bavel, Ed; Bakker, Erik Ntp; Hellstrand, Per; Bhattachariya, Anirban; Albinsson, Sebastian; Pincet, Frederic; Hallmann, Rupert
  
• Equilibrium physics breakdown reveals the active nature of red blood cell flickering. Nat Phys. 2016; 12: 513-519
  Turlier, H.; Fedosov, D. A.; Audoly, B.; Auth, T.; Gov, N. S.; Sykes, C.; Joanny, J.-F.; Gompper, G. & Betz, T.
  
• FGF23 signaling impairs neutrophil recruitment and host defense during CKD. J Clin Invest. 2016; 126: 962-974
  Rossaint, Jan; Oehmichen, Jessica; Van Aken, Hugo; Reuter, Stefan; Pavenstädt, Hermann J.; Meersch, Melanie; Unruh, Mark & Zarbock, Alexander
  
• Fluorinated matrix metalloproteinases inhibitors-Phosphonate based potential probes for positron emission tomography. Bioorg Med Chem. 2016; 24: 902-909
  Beutel, Bernd; Daniliuc, Constantin G.; Riemann, Burkhard; Schäfers, Michael & Haufe, Günter
  
• Gemcitabine Mechanism of Action Confounds Early Assessment of Treatment Response by 3'-Deoxy-3'-[18F]Fluorothymidine in Preclinical Models of Lung Cancer. Cancer Res. 2016; 76: 7096-7105
  Schelhaas, Sonja; Held, Annelena; Wachsmuth, Lydia; Hermann, Sven; Honess, Davina J.; Heinzmann, Kathrin; Smith, Donna-Michelle; Griffiths, John R.; Faber, Cornelius & Jacobs, Andreas H.
  
• Imaging by Elemental and Molecular Mass Spectrometry Reveals the Uptake of an Arsenolipid in the Brain of Drosophila melanogaster. Anal Chem. 2016; 88: 5258-5263
  Niehoff, Ann-Christin; Schulz, Jacqueline; Soltwisch, Jens; Meyer, Sören; Kettling, Hans; Sperling, Michael; Jeibmann, Astrid; Dreisewerd, Klaus; Francesconi, Kevin A.; Schwerdtle, Tanja & Karst, Uwe
  
• Imaging matrix metalloproteinase activity in multiple sclerosis as a specific marker of leukocyte penetration of the blood-brain barrier. Sci Transl Med. 2016; 8: 364ra152
  Gerwien, Hanna; Hermann, Sven; Zhang, Xueli; Korpos, Eva; Song, Jian; Kopka, Klaus; Faust, Andreas; Wenning, Christian; Gross, Catharina C.; Honold, Lisa; Melzer, Nico; Opdenakker, Ghislain; Wiendl, Heinz; Schäfers, Michael & Sorokin, Lydia
  
• Impaired NK-mediated regulation of T-cell activity in multiple sclerosis is reconstituted by IL-2 receptor modulation. Proc Natl Acad Sci USA. 2016; 113: E2973-82
  Gross, Catharina C.; Schulte-Mecklenbeck, Andreas; Rünzi, Anna; Kuhlmann, Tanja; Posevitz-Fejfár, Anita; Schwab, Nicholas; Schneider-Hohendorf, Tilman; Herich, Sebastian; Held, Kathrin; Konjević, Matea; Hartwig, Marvin; Dornmair, Klaus; Hohlfeld, Reinhard; Ziemssen, Tjalf; Klotz, Luisa; Meuth, Sven G. & Wiendl, Heinz
  
• Labeling and Selective Inactivation of Gram-Positive Bacteria Employing Bimodal Photoprobes with Dual Readouts. Chemistry. 2016; 22: 5243-5252
  Galstyan, Anzhela; Block, Desiree; Niemann, Silke; Grüner, Malte C.; Abbruzzetti, Stefania; Oneto, Michele; Daniliuc, Constantin G.; Hermann, Sven; Viappiani, Cristiano; Schäfers, Michael; Löffler, Bettina; Strassert, Cristian A. & Faust, Andreas
  
• Melanocortin-1 receptor activation is neuroprotective in mouse models of neuroinflammatory disease. Sci Transl Med. 2016; 8: 362ra146
  Mykicki, Nadine; Herrmann, Alexander M.; Schwab, Nicholas; Deenen, René; Sparwasser, Tim; Limmer, Andreas; Wachsmuth, Lydia; Klotz, Luisa; Köhrer, Karl; Faber, Cornelius; Wiendl, Heinz; Luger, Thomas A.; Meuth, Sven G. & Loser, Karin
  
• Modifying the 5'-Cap for Click Reactions of Eukaryotic mRNA and To Tune Translation Efficiency in Living Cells. Angew Chem Int Ed Engl. 2016; 55: 10899-10903
  Holstein, Josephin M.; Anhäuser, Lea & Rentmeister, Andrea
  
• Protection from septic peritonitis by rapid neutrophil recruitment through omental high endothelial venules. Nat Commun. 2016; 7: 10828
  Buscher, Konrad; Wang, Huiyu; Zhang, Xueli; Striewski, Paul; Wirth, Benedikt; Saggu, Gurpanna; Lütke-Enking, Stefan; Mayadas, Tanya N.; Ley, Klaus; Sorokin, Lydia & Song, Jian
  
• Radiolabeled Selective Matrix Metalloproteinase 13 (MMP-13) Inhibitors: (Radio)Syntheses and in Vitro and First in Vivo Evaluation. J Med Chem. 2017; 60: 307-321
  Hugenberg, Verena; Wagner, Stefan; Kopka, Klaus; Schäfers, Michael; Schuit, Robert C.; Windhorst, Albert D. & Hermann, Sven
  
• Repulsive cues combined with physical barriers and cell-cell adhesion determine progenitor cell positioning during organogenesis. Nat Commun. 2016; 7: 11288
  Paksa, Azadeh; Bandemer, Jan; Hoeckendorf, Burkhard; Razin, Nitzan; Tarbashevich, Katsiaryna; Minina, Sofia; Meyen, Dana; Biundo, Antonio; Leidel, Sebastian A.; Peyrieras, Nadine; Gov, Nir S.; Keller, Philipp J. & Raz, Erez
  
• Repulsive Epithelial Cues Direct Glial Migration along the Nerve. Dev Cell. 2016; 39: 696-707
  Sasse, Sofia & Klämbt, Christian
  
• Staccato/Unc-13-4 controls secretory lysosome-mediated lumen fusion during epithelial tube anastomosis. Nat Cell Biol. 2016; 18: 727-739
  Caviglia, Sara; Brankatschk, Marko; Fischer, Elisabeth J.; Eaton, Suzanne & Luschnig, Stefan
  
• A central region in the minor capsid protein of papillomaviruses facilitates viral genome tethering and membrane penetration for mitotic nuclear entry. PLoS Pathog. 2017; 13: e1006308
  Aydin, Inci; Villalonga-Planells, Ruth; Greune, Lilo; Bronnimann, Matthew P.; Calton, Christine M.; Becker, Miriam; Lai, Kun-Yi; Campos, Samuel K.; Schmidt, M. Alexander & Schelhaas, Mario
  
• A Novel Mouse Model of Staphylococcus aureus Vascular Graft Infection: Noninvasive Imaging of Biofilm Development in Vivo. Am J Pathol. 2017; 187: 268-279
  Van de Vyver, Hélène; Bovenkamp, Philipp R.; Hoerr, Verena; Schwegmann, Katrin; Tuchscherr, Lorena; Niemann, Silke; Kursawe, Laura; Grosse, Christina; Moter, Annette; Hansen, Uwe; Neugebauer, Ute; Kuhlmann, Michael T.; Peters, Georg; Hermann, Sven & Löffler, Bettina
  
• An Evolutionarily Conserved Role for Polydom/Svep1 During Lymphatic Vessel Formation. Circ Res. 2017; 120: 1263-1275
  Karpanen, Terhi; Padberg, Yvonne; van de Pavert, Serge A.; Dierkes, Cathrin; Morooka, Nanami; Peterson-Maduro, Josi; van de Hoek, Glenn; Adrian, Max; Mochizuki, Naoki; Sekiguchi, Kiyotoshi; Kiefer, Friedemann; Schulte, Dörte & Schulte-Merker, Stefan
  
• An FIM-Based Long-Term In-Vial Monitoring System for Drosophila Larvae. IEEE Trans Biomed Eng. 2017; 64: 1862-1874
  Berh, Dimitri; Risse, Benjamin; Michels, Tim; Otto, Nils; Jiang, Xiaoyi & Klambt, Christian
  
• Bleb Expansion in Migrating Cells Depends on Supply of Membrane from Cell Surface Invaginations. Dev Cell. 2017; 43: 577-587.e5
  Goudarzi, Mohammad; Tarbashevich, Katsiaryna; Mildner, Karina; Begemann, Isabell; Garcia, Jamie; Paksa, Azadeh; Reichman-Fried, Michal; Mahabaleshwar, Harsha; Blaser, Heiko; Hartwig, Johannes; Zeuschner, Dagmar; Galic, Milos; Bagnat, Michel; Betz, Timo & Raz, Erez
  
• Cell-matrix signals specify bone endothelial cells during developmental osteogenesis. Nat Cell Biol. 2017; 19: 189-201
  Langen, Urs H.; Pitulescu, Mara E.; Kim, Jung Mo; Enriquez-Gasca, Rocio; Sivaraj, Kishor K.; Kusumbe, Anjali P.; Singh, Amit; Di Russo, Jacopo; Bixel, M. Gabriele; Zhou, Bin; Sorokin, Lydia; Vaquerizas, Juan M. & Adams, Ralf H.
  
• Combined PET Imaging of the Inflammatory Tumor Microenvironment Identifies Margins of Unique Radiotracer Uptake. Cancer Res. 2017; 77: 1831-1841
  Zinnhardt, Bastian; Pigeon, Hayet; Thézé, Benoit; Viel, Thomas; Wachsmuth, Lydia; Fricke, Inga B.; Schelhaas, Sonja; Honold, Lisa; Schwegmann, Katrin; Wagner, Stefan; Faust, Andreas; Faber, Cornelius; Kuhlmann, Michael T.; Hermann, Sven; Schäfers, Michael; Winkeler, Alexandra & Jacobs, Andreas H.
  
• Dll4 and Notch signalling couples sprouting angiogenesis and artery formation. Nat Cell Biol. 2017; 19: 915-927
  Pitulescu, Mara E.; Schmidt, Inga; Giaimo, Benedetto Daniele; Antoine, Tobiah; Berkenfeld, Frank; Ferrante, Francesca; Park, Hongryeol; Ehling, Manuel; Biljes, Daniel; Rocha, Susana F.; Langen, Urs H.; Stehling, Martin; Nagasawa, Takashi; Ferrara, Napoleone; Borggrefe, Tilman & Adams, Ralf H.
  
• Endoglin controls blood vessel diameter through endothelial cell shape changes in response to haemodynamic cues. Nat Cell Biol. 2017; 19: 653-665
  Sugden, Wade W.; Meissner, Robert; Aegerter-Wilmsen, Tinri; Tsaryk, Roman; Leonard, Elvin V.; Bussmann, Jeroen; Hamm, Mailin J.; Herzog, Wiebke; Jin, Yi; Jakobsson, Lars; Denz, Cornelia & Siekmann, Arndt F.
  
• Endothelial Notch signalling limits angiogenesis via control of artery formation. Nat Cell Biol. 2017; 19: 928-940
  Hasan, Sana S.; Tsaryk, Roman; Lange, Martin; Wisniewski, Laura; Moore, John C.; Lawson, Nathan D.; Wojciechowska, Karolina; Schnittler, Hans & Siekmann, Arndt F.
  
• FIM2c : A Multicolour, Multipurpose Imaging System to Manipulate and Analyse Animal Behaviour. IEEE Trans Biomed Eng. 2017; 64: 610-620
  Risse, Benjamin; Otto, Nils; Berh, Dimitri; Jiang, Xiaoyi; Kiel, Matthias & Klambt, Christian
  
• FIMTrack: An open source tracking and locomotion analysis software for small animals. PLoS Comput Biol. 2017; 13: e1005530
  Risse, Benjamin; Berh, Dimitri; Otto, Nils; Klämbt, Christian & Jiang, Xiaoyi
  
• Generic wound signals initiate regeneration in missing-tissue contexts. Nat Commun. 2017; 8: 2282
  Owlarn, Suthira; Klenner, Felix; Schmidt, David; Rabert, Franziska; Tomasso, Antonio; Reuter, Hanna; Mulaw, Medhanie A.; Moritz, Sören; Gentile, Luca; Weidinger, Gilbert & Bartscherer, Kerstin
  
• Mutations in KEOPS-complex genes cause nephrotic syndrome with primary microcephaly. Nat Genet. 2017; 49: 1529-1538
  Braun, Daniela A; Rao, Jia; Mollet, Geraldine; Schapiro, David; Daugeron, Marie-Claire; Tan, Weizhen; Gribouval, Olivier; Boyer, Olivia; Revy, Patrick; Jobst-Schwan, Tilman; Schmidt, Johanna Magdalena; Lawson, Jennifer A; Schanze, Denny; Ashraf, Shazia; Ullmann, Jeremy F P; Hoogstraten, Charlotte A; Boddaert, Nathalie; Collinet, Bruno; Martin, Gaëlle; ... & Hildebrandt, Friedhelm
  
• Optimal Micropatterns in 2D Transport Networks and Their Relation to Image Inpainting. Arch Rational Mech Anal. 2018; 228: 279-308
  Brancolini, Alessio; Rossmanith, Carolin & Wirth, Benedikt
  
• PAR-1 promotes microtubule breakdown during dendrite pruning in Drosophila. EMBO J. 2017; 36: 1981-1991
  Herzmann, Svende; Krumkamp, Rafael; Rode, Sandra; Kintrup, Carina & Rumpf, Sebastian
  
• Polarized actin and VE-cadherin dynamics regulate junctional remodelling and cell migration during sprouting angiogenesis. Nat Commun. 2017; 8 (1): 2210
  Cao, Jiahui; Ehling, Manuel; März, Sigrid; Seebach, Jochen; Tarbashevich, Katsiaryna; Sixta, Tomas; Pitulescu, Mara E.; Werner, Ann-Cathrin; Flach, Boris; Montanez, Eloi; Raz, Erez; Adams, Ralf H. & Schnittler, Hans
  
• Reversible Stabilization of Vesicles: Redox-Responsive Polymer Nanocontainers for Intracellular Delivery. Angew Chem Int Ed Engl. 2017; 56: 9603-9607
  de Vries, Wilke C.; Grill, David; Tesch, Matthias; Ricker, Andrea; Nüsse, Harald; Klingauf, Jürgen; Studer, Armido; Gerke, Volker & Ravoo, Bart Jan
  
• S100-alarmin-induced innate immune programming protects newborn infants from sepsis. Nat Immunol. 2017; 18: 622-632
  Ulas, Thomas; Pirr, Sabine; Fehlhaber, Beate; Bickes, Marie S; Loof, Torsten G; Vogl, Thomas; Mellinger, Lara; Heinemann, Anna S; Burgmann, Johanna; Schöning, Jennifer; Schreek, Sabine; Pfeifer, Sandra; Reuner, Friederike; Völlger, Lena; Stanulla, Martin; von Köckritz-Blickwede, Maren; Glander, Shirin; Barczyk-Kahlert, Katarzyna; von Kaisenberg, Constantin S; ... & Viemann, Dorothee
  
• VGLUT1 functions as a glutamate/proton exchanger with chloride channel activity in hippocampal glutamatergic synapses. Nat Commun. 2017; 8: 2279
  Martineau, Magalie; Guzman, Raul E.; Fahlke, Christoph & Klingauf, Jürgen
  
• VIPAR, a quantitative approach to 3D histopathology applied to lymphatic malformations. JCI Insight. 2017; 2
  Hägerling, René; Drees, Dominik; Scherzinger, Aaron; Dierkes, Cathrin; Martin-Almedina, Silvia; Butz, Stefan; Gordon, Kristiana; Schäfers, Michael; Hinrichs, Klaus; Ostergaard, Pia; Vestweber, Dietmar; Goerge, Tobias; Mansour, Sahar; Jiang, Xiaoyi; Mortimer, Peter S. & Kiefer, Friedemann
  
• Addressable Cholesterol Analogs for Live Imaging of Cellular Membranes. Cell Chem Biol. 2018; 25: 952-961.e12
  Rakers, Lena; Grill, David; Matos, Anna L.L.; Wulff, Stephanie; Wang, Da; Börgel, Jonas; Körsgen, Martin; Arlinghaus, Heinrich F.; Galla, Hans-Joachim; Gerke, Volker & Glorius, Frank
  
• Autoinhibitory regulation of S100A8/S100A9 alarmin activity locally restricts sterile inflammation. J Clin Invest. 2018; 128: 1852-1866
  Vogl, Thomas; Stratis, Athanasios; Wixler, Viktor; Völler, Tom; Thurainayagam, Sumita; Jorch, Selina K.; Zenker, Stefanie; Dreiling, Alena; Chakraborty, Deblina; Fröhling, Mareike; Paruzel, Peter; Wehmeyer, Corinna; Hermann, Sven; Papantonopoulou, Olympia; Geyer, Christiane; Loser, Karin; Schäfers, Michael; Ludwig, Stephan; Stoll, Monika; ... & Roth, Johannes
  
• CD99L2 deficiency inhibits leukocyte entry into the central nervous system and ameliorates neuroinflammation. J Leukoc Biol. 2018; 104: 787-797
  Samus, Maryna; Seelige, Ruth; Schäfer, Kerstin; Sorokin, Lydia & Vestweber, Dietmar
  
• Codon-specific translation reprogramming promotes resistance to targeted therapy. Nature. 2018; 558: 605-609
  Rapino, Francesca; Delaunay, Sylvain; Rambow, Florian; Zhou, Zhaoli; Tharun, Lars; De Tullio, Pascal; Sin, Olga; Shostak, Kateryna; Schmitz, Sebastian; Piepers, Jolanda; Ghesquière, Bart; Karim, Latifa; Charloteaux, Benoit; Jamart, Diane; Florin, Alexandra; Lambert, Charles; Rorive, Andrée; Jerusalem, Guy; Leucci, Eleonora; ... & Close, Pierre
  
• Collective Cell Migration in Embryogenesis Follows the Laws of Wetting. Biophys J. 2018; 114: 213-222
  Wallmeyer, Bernhard; Trinschek, Sarah; Yigit, Sargon; Thiele, Uwe & Betz, Timo
  
• Development of Novel Quinoxaline-Based kappa-Opioid Receptor Agonists for the Treatment of Neuroinflammation. J Med Chem. 2019; 62: 893-907
  Tangherlini, Giovanni; Kalinin, Dmitrii V.; Schepmann, Dirk; Che, Tao; Mykicki, Nadine; Ständer, Sonja; Loser, Karin & Wünsch, Bernhard
  
• Distinct roles of VE‐cadherin for development and maintenance of specific lymph vessel beds. EMBO J. 2018: e98271
  Hägerling, René; Hoppe, Esther; Dierkes, Cathrin; Stehling, Martin; Makinen, Taija; Butz, Stefan; Vestweber, Dietmar & Kiefer, Friedemann
  
• Enzymatic or In Vivo Installation of Propargyl Groups in Combination with Click Chemistry for the Enrichment and Detection of Methyltransferase Target Sites in RNA. Angew Chem Int Ed Engl. 2018; 57: 6342-6346
  Hartstock, Katja; Nilges, Benedikt S.; Ovcharenko, Anna; Cornelissen, Nicolas V.; Püllen, Nikolai; Lawrence‐Dörner, Ann‐Marie; Leidel, Sebastian A. & Rentmeister, Andrea
  
• Harnessing the Maltodextrin Transport Mechanism for Targeted Bacterial Imaging: Structural Requirements for Improved in vivo Stability in Tracer Design. Chem Med Chem. 2018; 13: 241-250
  Axer, Alexander; Hermann, Sven; Kehr, Gerald; Clases, David; Karst, Uwe; Fischer‐Riepe, Lena; Roth, Johannes; Fobker, Manfred; Schäfers, Michael; Gilmour, Ryan & Faust, Andreas
  
• Human T cells in silico: Modelling dynamic intracellular calcium and its influence on cellular electrophysiology. J Immunol Methods. 2018; 461: 78-84
  Eichinger, Paul; Herrmann, Alexander M.; Ruck, Tobias; Herty, Michael; Gola, Lukas; Kovac, Stjepana; Budde, Thomas; Meuth, Sven G. & Hundehege, Petra
  
• Imaging, myeloid precursor immortalization, and genome editing for defining mechanisms of leukocyte recruitment in vivo. Theranostics. 2018; 8: 2407-2423
  Gran, Sandra; Honold, Lisa; Fehler, Olesja; Zenker, Stefanie; Eligehausen, Sarah; Kuhlmann, Michael T.; Geven, Edwin; den Bosch, Martijn van; van Lent, Peter; Spiekermann, Christoph; Hermann, Sven; Vogl, Thomas; Schäfers, Michael & Roth, Johannes
  
• Lateral plasma membrane compartmentalization links protein function and turnover. Embo J. 2018; 37: e99473
  Busto, Jon V; Elting, Annegret; Haase, Daniel; Spira, Felix; Kuhlman, Julian; Schäfer‐Herte, Marco & Wedlich‐Söldner, Roland
  
• Molecular imaging of MMP activity discriminates unstable from stable plaque phenotypes in shear-stress induced murine atherosclerosis. PLoS One. 2018; 13: e0204305
  Seifert, Robert; Kuhlmann, Michael T.; Eligehausen, Sarah; Kiefer, Friedemann; Hermann, Sven & Schäfers, Michael
  
• New in Vivo Compatible Matrix Metalloproteinase (MMP)-2 and MMP-9 Inhibitors. Bioconjug Chem. 2018; 29: 3715-3725
  Beutel, Bernd; Song, Jian; Konken, Christian Paul; Korpos, Eva; Schinor, Benjamin; Gerwien, Hanna; Vidyadharan, Reshma; Burmeister, Miriam; Li, Lixia; Haufe, Günter & Sorokin, Lydia
  
• Polarized microtubule dynamics directs cell mechanics and coordinates forces during epithelial morphogenesis. Nat Cell Biol. 2018; 20: 1126-1133
  Singh, Amrita; Saha, Tanumoy; Begemann, Isabell; Ricker, Andrea; Nüsse, Harald; Thorn-Seshold, Oliver; Klingauf, Jürgen; Galic, Milos & Matis, Maja
  
• The sulfite oxidase Shopper controls neuronal activity by regulating glutamate homeostasis in Drosophila ensheathing glia. Nat Commun. 2018; 9: 3514
  Otto, Nils; Marelja, Zvonimir; Schoofs, Andreas; Kranenburg, Holger; Bittern, Jonas; Yildirim, Kerem; Berh, Dimitri; Bethke, Maria; Thomas, Silke; Rode, Sandra; Risse, Benjamin; Jiang, Xiaoyi; Pankratz, Michael; Leimkühler, Silke & Klämbt, Christian
  
• An RJMCMC-Based Method for Tracking and Resolving Collisions of Drosophila Larvae. IEEE/ACM Trans Comput Biol Bioinform. 2019; 16: 465-474
  Michels, Tim; Berh, Dimitri & Jiang, Xiaoyi
  
• EZH2 Inhibition in Ewing Sarcoma Upregulates GD2 Expression for Targeting with Gene-Modified T Cells. Mol Ther. 2019; 27: 933-946
  Kailayangiri, Sareetha; Altvater, Bianca; Lesch, Stefanie; Balbach, Sebastian; Göttlich, Claudia; Kühnemundt, Johanna; Mikesch, Jan-Henrik; Schelhaas, Sonja; Jamitzky, Silke; Meltzer, Jutta; Farwick, Nicole; Greune, Lea; Fluegge, Maike; Kerl, Kornelius; Lode, Holger N.; Siebert, Nikolai; Müller, Ingo; Walles, Heike; Hartmann, Wolfgang; ... & Rossig, Claudia
  
• Introducing Specificity to Iron Oxide Nanoparticle Imaging by Combining (57)Fe-Based MRI and Mass Spectrometry. Nano Lett. 2019
  Masthoff, Max; Buchholz, Rebecca; Beuker, Andre; Wachsmuth, Lydia; Kraupner, Alexander; Albers, Franziska; Freppon, Felix; Helfen, Anne; Gerwing, Mirjam; Höltke, Carsten; Hansen, Uwe; Rehkämper, Jan; Vielhaber, Torsten; Heindel, Walter; Eisenblätter, Michel; Karst, Uwe; Wildgruber, Moritz & Faber, Cornelius
  
• Loss of the transcription factor RBPJ induces disease-promoting properties in brain pericytes. Nat Commun. 2019; 10: 2817
  Diéguez-Hurtado, Rodrigo; Kato, Katsuhiro; Giaimo, Benedetto Daniele; Nieminen-Kelhä, Melina; Arf, Hendrik; Ferrante, Francesca; Bartkuhn, Marek; Zimmermann, Tobias; Bixel, M. Gabriele; Eilken, Hanna M.; Adams, Susanne; Borggrefe, Tilman; Vajkoczy, Peter & Adams, Ralf H.
  
• Mechanochemical self-organization determines search pattern in migratory cells. Nat Phys. 2019; 15: 848-857
  Begemann, I.; Saha, T.; Lamparter, L.; Rathmann, I.; Grill, D.; Golbach, L.; Rasch, C.; Keller, U.; Trappmann, B.; Matis, M.; Gerke, V.; Klingauf, J. & Galic, M.
  
• Polarization nano-tomography of tightly focused light landscapes by self-assembled monolayers. Nat Commun. 2019; 10: 4308
  Otte, Eileen; Tekce, Kemal; Lamping, Sebastian; Ravoo, Bart Jan & Denz, Cornelia
  
• Portable all-fiber dual-output widely tunable light source for coherent Raman imaging. Biomed Opt Express. 2019; 10: 4437-4449
  Brinkmann, Maximilian; Fast, Alexander; Hellwig, Tim; Pence, Isaac; Evans, Conor L. & Fallnich, Carsten
  
• Rab11 is required for neurite pruning and developmental membrane protein degradation in Drosophila sensory neurons. Dev Biol. 2019; 451: 68-78
  Krämer, Rafael; Rode, Sandra & Rumpf, Sebastian
  
• Stereospecific alpha-Sialylation by Site-Selective Fluorination. Angew Chem Int Ed Engl. 2019; 58: 3814-3818
  Hayashi, Taiki; Kehr, Gerald; Bergander, Klaus & Gilmour, Ryan