EXC 1003:  Cells in Motion - CiM: Imaging to Understand Cellular Behaviour in Organisms

• Subject Area: Basic Research in Biology and Medicine
• Term: from 2012 to 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 194347757

• Final Report Year: 2019

Final Report Abstract

Dynamic cellular behaviour determines development, tissue homeostasis and regeneration. Over the past decade, live imaging strategies have revolutionised our perception of cellular behaviour and emphasised their dynamic nature, a topic to which the ‘Cells in Motion – CiM’ Cluster of Excellence has contributed significantly at national and international levels. Based on its broad interdisciplinary expertise CiM has overcome several existing limitations in optical and medical imaging and has deciphered crucial aspects of cellular behaviour in organisms by analysing systems of increasing complexity. Central to the CiM concept has been the use and development of novel imaging strategies to optimise temporal-spatial resolution and specificity. Our vision remains to promote an interfaculty environment boosting basic biomedical sciences and clinical translation and their interaction using imaging as a common strategy to understand cellular behaviour, regardless of whether this is in cells or tissues, in disease models or in patients. To foster knowledge transfer and scientific creativity we have overcome traditional barriers between faculties by establishing seven new interdisciplinary and two new clinical translational professorships, and a unique Cells in Motion Interfaculty Centre (CiMIC), housed in a new building, the Multiscale Imaging Centre (MIC), supported by WWU funding. Integral to our concept has been a new interfaculty educational structure (Careers in Motion Centre) that promotes gender equality and diversity, and includes a novel Master in ‘Experimental Medicine’ allowing medical students to enter into a structured PhD programme. This will continue to promote high quality clinical research and translation of basic science to the clinic. CiM has successfully and uniquely merged excellence at WWU in cell biology and molecular imaging and integrated interdisciplinary networks between the medical, natural sciences and mathematics faculties as well as the Max Planck Institute for Molecular Biomedicine (MPI), documented in several coordinated national and European programmes. The cluster has been a prime example of a new interactive and long-term sustainable structure linking the participating faculties in research and education. CiM has, thereby, changed the research landscape at WWU and has created a unique academic environment that strongly enhances the national and international visibility of WWU in the field of natural sciences and medicine. It will continue to promote excellence in biomedical research in Germany by the establishment of new Collaborative Research Centres and research networks, supported by CiMIC, and exploiting cutting-edge imaging techniques to address fundamental questions in cell biology and their application to diagnostics and therapy.

Link to the final report

https://doi.org/10.2314/KXP:170112324X

Publications

• Bacteria tracking by in vivo magnetic resonance imaging. BMC Biol. 2013; 11: 63
  Hoerr, Verena; Tuchscherr, Lorena; Hüve, Jana; Nippe, Nadine; Loser, Karin; Glyvuk, Nataliya; Tsytsyura, Yaroslav; Holtkamp, Michael; Sunderkötter, Cord; Karst, Uwe; Klingauf, Jürgen; Peters, Georg; Löffler, Bettina & Faber, Cornelius
  
• Blocking endocytosis enhances short-term synaptic depression under conditions of normal availability of vesicles. Neuron. 2013; 80: 343-349
  Hua, Yunfeng; Woehler, Andrew; Kahms, Martin; Haucke, Volker; Neher, Erwin & Klingauf, Jürgen
  
• cAMP-induced secretion of endothelial von Willebrand factor is regulated by a phosphorylation/dephosphorylation switch in annexin A2. Blood. 2013; 122: 1042-1051
  Brandherm, Ines; Disse, Jennifer; Zeuschner, Dagmar & Gerke, Volker
  
• Endothelial TWIK-related potassium channel-1 (TREK1) regulates immune-cell trafficking into the CNS. Nat Med. 2013; 19: 1161-1165
  Bittner, Stefan; Ruck, Tobias; Schuhmann, Michael K.; Herrmann, Alexander M.; Maati, Hamid Moha Ou; Bobak, Nicole; Göbel, Kerstin; Langhauser, Friederike; Stegner, David; Ehling, Petra; Borsotto, Marc; Pape, Hans-Christian; Nieswandt, Bernhard; Kleinschni
  
• FIM, a novel FTIR-based imaging method for high throughput locomotion analysis. PLoS One. 2013; 8: e53963
  Risse, Benjamin; Thomas, Silke; Otto, Nils; Löpmeier, Tim; Valkov, Dimitar; Jiang, Xiaoyi & Klämbt, Christian
  
• Alarmin S100A8/S100A9 as a biomarker for molecular imaging of local inflammatory activity. Nat Commun. 2014; 5: 4593
  Vogl, Thomas; Eisenblätter, Michel; Völler, Tom; Zenker, Stefanie; Hermann, Sven; van Lent, Peter; Faust, Andreas; Geyer, Christiane; Petersen, Beatrix; Roebrock, Kirsten; Schäfers, Michael; Bremer, Christoph & Roth, Johannes
  
• Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone. Nature. 2014; 507: 323-328
  Kusumbe, Anjali P.; Ramasamy, Saravana K. & Adams, Ralf H.
  
• Differential phospholipase C-dependent modulation of TASK and TREK two-pore domain K+ channels in rat thalamocortical relay neurons. J Physiol. 2015; 593: 127-144
  Bista, Pawan; Pawlowski, Matthias; Cerina, Manuela; Ehling, Petra; Leist, Michael; Meuth, Patrick; Aissaoui, Ania; Borsotto, Marc; Heurteaux, Catherine; Decher, Niels; Pape, Hans‐Christian; Oliver, Dominik; Meuth, Sven G. & Budde, Thomas
  
• Ena/VASP Proteins Cooperate with the WAVE Complex to Regulate the Actin Cytoskeleton. Dev Cell. 2014; 30: 569-584
  Chen, Xing Judy; Squarr, Anna Julia; Stephan, Raiko; Chen, Baoyu; Higgins, Theresa E.; Barry, David J.; Martin, Morag C.; Rosen, Michael K.; Bogdan, Sven & Way, Michael
  
• Endothelial Notch activity promotes angiogenesis and osteogenesis in bone. Nature. 2014; 507: 376-380
  Ramasamy, Saravana K.; Kusumbe, Anjali P.; Wang, Lin & Adams, Ralf H.
  
• Fusing VE-Cadherin to alpha-Catenin Impairs Fetal Liver Hematopoiesis and Lymph but Not Blood Vessel Formation. Mol Cell Biol. 2014; 34: 1634-1648
  Dartsch, Nina; Schulte, Dörte; Hägerling, René; Kiefer, Friedemann & Vestweber, Dietmar
  
• Large Scale RNAi Reveals the Requirement of Nuclear Envelope Breakdown for Nuclear Import of Human Papillomaviruses. PLoS Pathog. 2014; 10: e1004162
  Aydin, Inci; Weber, Susanne; Snijder, Berend; Samperio Ventayol, Pilar; Kühbacher, Andreas; Becker, Miriam; Day, Patricia M.; Schiller, John T.; Kann, Michael; Pelkmans, Lucas; Helenius, Ari & Schelhaas, Mario
  
• Leukocyte extravasation and vascular permeability are each controlled in vivo by different tyrosine residues of VE-cadherin. Nat Immunol. 2014; 15: 223-230
  Wessel, Florian; Winderlich, Mark; Holm, Maren; Frye, Maike; Rivera-Galdos, Ronmy; Vockel, Matthias; Linnepe, Ruth; Ipe, Ute; Stadtmann, Anika; Zarbock, Alexander; Nottebaum, Astrid F & Vestweber, Dietmar
  
• Serial F-18-FDG PET/CT distinguishes inflamed from stable plaque phenotypes in shear-stress induced murine atherosclerosis. Atherosclerosis. 2014; 234: 276-282
  Wenning, Christian; Kloth, Christopher; Kuhlmann, Michael T.; Jacobs, Andreas H.; Schober, Otmar; Hermann, Sven & Schäfers, Michael A.
  
• The Drosophila FHOD1-like formin Knittrig acts through Rok to promote stress fiber formation and directed macrophage migration during the cellular immune response. Development. 2014; 141: 1366-1380
  Lammel, Uwe; Bechtold, Meike; Risse, Benjamin; Berh, Dimitri; Fleige, Astrid; Bunse, Ingrid; Jiang, Xiaoyi; Klämbt, Christian & Bogdan, Sven
  
• Total variation regularization in measurement and image space for PET reconstruction. Inverse Probl. 2014; 30: 105003
  Burger, M.; Müller, J.; Papoutsellis, E. & Schönlieb, C. B.
  
• Ultraviolet B light attenuates the systemic immune response in central nervous system autoimmunity. Ann Neurol. 2014; 75: 739-758
  Breuer, Johanna; Schwab, Nicholas; Schneider‐Hohendorf, Tilman; Marziniak, Martin; Mohan, Hema; Bhatia, Urvashi; Gross, Catharina C.; Clausen, Björn E.; Weishaupt, Carsten; Luger, Thomas A.; Meuth, Sven G.; Loser, Karin & Wiendl, Heinz
  
• Viral suppressors of the RIG-I-mediated interferon response are pre-packaged in influenza virions. Nat Commun. 2014; 5: 5645
  Liedmann, Swantje; Hrincius, Eike R.; Guy, Cliff; Anhlan, Darisuren; Dierkes, Rüdiger; Carter, Robert; Wu, Gang; Staeheli, Peter; Green, Douglas R.; Wolff, Thorsten; McCullers, Jonathan A.; Ludwig, Stephan & Ehrhardt, Christina
  
• VLA-4 blockade promotes differential routes into human CNS involving PSGL-1 rolling of T cells and MCAM- adhesion of TH17 cells. J Exp Med. 2014; 211: 1833-1846
  Schneider-Hohendorf, Tilman; Rossaint, Jan; Mohan, Hema; Böning, Daniel; Breuer, Johanna; Kuhlmann, Tanja; Gross, Catharina C.; Flanagan, Ken; Sorokin, Lydia; Vestweber, Dietmar; Zarbock, Alexander; Schwab, Nicholas & Wiendl, Heinz
  
• A Bio-Inspired, Catalytic E --> Z Isomerization of Activated Olefins. J Am Chem Soc. 2015; 137: 11254-11257
  Metternich, Jan B. & Gilmour, Ryan
  
• A Dynamic Unfolded Protein Response Contributes to the Control of Cortical Neurogenesis. Developmental Cell. 2015; 35: 553-567
  Laguesse, Sophie; Creppe, Catherine; Nedialkova, Danny D.; Prévot, Pierre-Paul; Borgs, Laurence; Huysseune, Sandra; Franco, Bénédicte; Duysens, Guérin; Krusy, Nathalie; Lee, Gabsang; Thelen, Nicolas; Thiry, Marc; Close, Pierre; Chariot, Alain; Malgrange, Brigitte; Leidel, Sebastian A.; Godin, Juliette D. & Nguyen, Laurent
  
• A novel family of fluorescent hypoxia sensors reveal strong heterogeneity in tumor hypoxia at the cellular level. Embo J. 2016; 35: 102-113
  Erapaneedi, Raghu; Belousov, Vsevolod V; Schäfers, Michael & Kiefer, Friedemann
  
• Blocking neutrophil diapedesis prevents hemorrhage during thrombocytopenia. J Exp Med. 2015; 212: 1255-1266
  Hillgruber, Carina; Pöppelmann, Birgit; Weishaupt, Carsten; Steingräber, Annika Kathrin; Wessel, Florian; Berdel, Wolfgang E.; Gessner, J. Engelbert; Ho-Tin-Noé, Benoît; Vestweber, Dietmar & Goerge, Tobias
  
• CD8+ T cell-mediated neuronal dysfunction and degeneration in limbic encephalitis. Front Neurol. 2015; 6: 163
  Ehling, Petra; Melzer, Nico; Budde, Thomas & Meuth, Sven G.
  
• Focal MMP-2 and MMP-9 Activity at the Blood-Brain Barrier Promotes Chemokine-Induced Leukocyte Migration. Cell Rep. 2015; 10: 1040-1054
  Song, Jian; Wu, Chuan; Korpos, Eva; Zhang, Xueli; Agrawal, Smriti M.; Wang, Ying; Faber, Cornelius; Schäfers, Michael; Körner, Heinrich; Opdenakker, Ghislain; Hallmann, Rupert & Sorokin, Lydia
  
• Influence of cell shape, inhomogeneities and diffusion barriers in cell polarization models. Phys Biol. 2015; 12: 066014
  Giese, Wolfgang; Eigel, Martin; Westerheide, Sebastian; Engwer, Christian & Klipp, Edda
  
• Interfering with VE-PTP stabilizes endothelial junctions in vivo via Tie-2 in the absence of VE-cadherin. J Exp Med. 2015; 212: 2267-2287
  Frye, Maike; Dierkes, Martina; Küppers, Verena; Vockel, Matthias; Tomm, Janina; Zeuschner, Dagmar; Rossaint, Jan; Zarbock, Alexander; Koh, Gou Young; Peters, Kevin; Nottebaum, Astrid Fee & Vestweber, Dietmar
  
• JAM-A regulates cortical dynein localization through Cdc42 to control planar spindle orientation during mitosis. Nat Commun. 2015; 6: 8128
  Tuncay, Hüseyin; Brinkmann, Benjamin F.; Steinbacher, Tim; Schürmann, Annika; Gerke, Volker; Iden, Sandra & Ebnet, Klaus
  
• Multimodal imaging reveals temporal and spatial microglia and matrix metalloproteinase activity after experimental stroke. J Cereb Blood Flow Metab.2015; 35: 1711-1721
  Zinnhardt, Bastian; Viel, Thomas; Wachsmuth, Lydia; Vrachimis, Alexis; Wagner, Stefan; Breyholz, Hans-Jörg; Faust, Andreas; Hermann, Sven; Kopka, Klaus; Faber, Cornelius; Dollé, Frédéric; Pappata, Sabina; Planas, Anna M.; Tavitian, Bertrand; Schäfers, Mic
  
• Optimization of Codon Translation Rates via tRNA Modifications Maintains Proteome Integrity. Cell. 2015; 161: 1606-1618
  Nedialkova, Danny D. & Leidel, Sebastian A.
  
• Puzzle Approach to Pose Tracking of a Rigid Object in a Multi Camera System. Lect Notes Comput Sc. 2015; 9256: 337-349
  Schmid, Sönke; Jiang, Xiaoyi & Schäfers, Klaus
  
• The motorized RhoGAP myosin IXb (Myo9b) in leukocytes regulates experimental autoimmune encephalomyelitis induction and recovery. J Neuroimmunol. 2015; 282: 25-32
  Liu, Zhijun; Xu, Yan; Zhang, Xueli; Song, Jian; Sorokin, Lydia & Bähler, Martin
  
• The Triple-Repeat Protein Anakonda Controls Epithelial Tricellular Junction Formation in Drosophila. Dev Cell. 2015; 33: 535-548
  Byri, Sunitha; Misra, Tvisha; Syed, Zulfeqhar A.; Bätz, Tilmann; Shah, Jimit; Boril, Lukas; Glashauser, Jade; Aegerter-Wilmsen, Tinri; Matzat, Till; Moussian, Bernard; Uv, Anne & Luschnig, Stefan
  
• Age-dependent modulation of vascular niches for haematopoietic stem cells. Nature. 2016; 532: 380-384
  Kusumbe, Anjali P.; Ramasamy, Saravana K.; Itkin, Tomer; Mäe, Maarja Andaloussi; Langen, Urs H.; Betsholtz, Christer; Lapidot, Tsvee & Adams, Ralf H.
  
• Cannabinoid Receptor 2 Modulates Susceptibility to Experimental Cerebral Malaria through a CCL17-dependent Mechanism. J Biol Chem. 2016; 291: 19517-19531
  Alferink, Judith; Specht, Sabine; Arends, Hannah; Schumak, Beatrix; Schmidt, Kim; Ruland, Christina; Lundt, Ramona; Kemter, Andrea; Dlugos, Andrea; Kuepper, Janina M.; Poppensieker, Karola; Findeiss, Matthias; Albayram, Önder; Otte, David-M.; Marazzi, Janine; Gertsch, Jürg; Förster, Irmgard; Maier, Wolfgang; Scheu, Stefanie; ... & Zimmer, Andreas
  
• Changing POU dimerization preferences converts Oct6 into a pluripotency inducer. EMBO Rep. 2017; 18: 319-333
  Jerabek, Stepan; Ng, Calista KL; Wu, Guangming; Arauzo‐Bravo, Marcos J; Kim, Kee‐Pyo; Esch, Daniel; Malik, Vikas; Chen, Yanpu; Velychko, Sergiy; MacCarthy, Caitlin M; Yang, Xiaoxiao; Cojocaru, Vlad; Schöler, Hans R & Jauch, Ralf
  
• Combinatorial effects of doxorubicin and retargeted tissue factor by intratumoral entrapment of doxorubicin and proapoptotic increase of tumor vascular infarction. Oncotarget. 2016; 7: 82458-82472
  Stucke-Ring, Janine; Ronnacker, Julian; Brand, Caroline; Höltke, Carsten; Schliemann, Christoph; Kessler, Torsten; Schmidt, Lars Henning; Harrach, Saliha; Mantke, Verena; Hintelmann, Heike; Hartmann, Wolfgang; Wardelmann, Eva; Lenz, Georg; Wünsch, Bernhard; Müller-Tidow, Carsten; Mesters, Rolf M.; Schwöppe, Christian & Berdel, Wolfgang E.
  
• Directed transport of neutrophil-derived extracellular vesicles enables platelet-mediated innate immune response. Nat Commun. 2016; 7: 13464
  Rossaint, Jan; Kühne, Katharina; Skupski, Jennifer; Van Aken, Hugo; Looney, Mark R.; Hidalgo, Andres & Zarbock, Alexander
  
• Endothelial basement membrane laminin 511 is essential for shear stress response. EMBO J. 2017; 36: 183-201
  Di Russo, Jacopo; Luik, Anna‐Liisa; Yousif, Lema; Budny, Sigmund; Oberleithner, Hans; Hofschröer, Verena; Klingauf, Juergen; Van Bavel, Ed; Bakker, Erik Ntp; Hellstrand, Per; Bhattachariya, Anirban; Albinsson, Sebastian; Pincet, Frederic; Hallmann, Rupert
  
• Equilibrium physics breakdown reveals the active nature of red blood cell flickering. Nat Phys. 2016; 12: 513-519
  Turlier, H.; Fedosov, D. A.; Audoly, B.; Auth, T.; Gov, N. S.; Sykes, C.; Joanny, J.-F.; Gompper, G. & Betz, T.
  
• FGF23 signaling impairs neutrophil recruitment and host defense during CKD. J Clin Invest. 2016; 126: 962-974
  Rossaint, Jan; Oehmichen, Jessica; Van Aken, Hugo; Reuter, Stefan; Pavenstädt, Hermann J.; Meersch, Melanie; Unruh, Mark & Zarbock, Alexander
  
• Fluorinated matrix metalloproteinases inhibitors-Phosphonate based potential probes for positron emission tomography. Bioorg Med Chem. 2016; 24: 902-909
  Beutel, Bernd; Daniliuc, Constantin G.; Riemann, Burkhard; Schäfers, Michael & Haufe, Günter
  
• Gemcitabine Mechanism of Action Confounds Early Assessment of Treatment Response by 3'-Deoxy-3'-[18F]Fluorothymidine in Preclinical Models of Lung Cancer. Cancer Res. 2016; 76: 7096-7105
  Schelhaas, Sonja; Held, Annelena; Wachsmuth, Lydia; Hermann, Sven; Honess, Davina J.; Heinzmann, Kathrin; Smith, Donna-Michelle; Griffiths, John R.; Faber, Cornelius & Jacobs, Andreas H.
  
• Imaging by Elemental and Molecular Mass Spectrometry Reveals the Uptake of an Arsenolipid in the Brain of Drosophila melanogaster. Anal Chem. 2016; 88: 5258-5263
  Niehoff, Ann-Christin; Schulz, Jacqueline; Soltwisch, Jens; Meyer, Sören; Kettling, Hans; Sperling, Michael; Jeibmann, Astrid; Dreisewerd, Klaus; Francesconi, Kevin A.; Schwerdtle, Tanja & Karst, Uwe
  
• Imaging matrix metalloproteinase activity in multiple sclerosis as a specific marker of leukocyte penetration of the blood-brain barrier. Sci Transl Med. 2016; 8: 364ra152
  Gerwien, Hanna; Hermann, Sven; Zhang, Xueli; Korpos, Eva; Song, Jian; Kopka, Klaus; Faust, Andreas; Wenning, Christian; Gross, Catharina C.; Honold, Lisa; Melzer, Nico; Opdenakker, Ghislain; Wiendl, Heinz; Schäfers, Michael & Sorokin, Lydia
  
• Impaired NK-mediated regulation of T-cell activity in multiple sclerosis is reconstituted by IL-2 receptor modulation. Proc Natl Acad Sci USA. 2016; 113: E2973-82
  Gross, Catharina C.; Schulte-Mecklenbeck, Andreas; Rünzi, Anna; Kuhlmann, Tanja; Posevitz-Fejfár, Anita; Schwab, Nicholas; Schneider-Hohendorf, Tilman; Herich, Sebastian; Held, Kathrin; Konjević, Matea; Hartwig, Marvin; Dornmair, Klaus; Hohlfeld, Reinhard; Ziemssen, Tjalf; Klotz, Luisa; Meuth, Sven G. & Wiendl, Heinz
  
• Labeling and Selective Inactivation of Gram-Positive Bacteria Employing Bimodal Photoprobes with Dual Readouts. Chemistry. 2016; 22: 5243-5252
  Galstyan, Anzhela; Block, Desiree; Niemann, Silke; Grüner, Malte C.; Abbruzzetti, Stefania; Oneto, Michele; Daniliuc, Constantin G.; Hermann, Sven; Viappiani, Cristiano; Schäfers, Michael; Löffler, Bettina; Strassert, Cristian A. & Faust, Andreas
  
• Melanocortin-1 receptor activation is neuroprotective in mouse models of neuroinflammatory disease. Sci Transl Med. 2016; 8: 362ra146
  Mykicki, Nadine; Herrmann, Alexander M.; Schwab, Nicholas; Deenen, René; Sparwasser, Tim; Limmer, Andreas; Wachsmuth, Lydia; Klotz, Luisa; Köhrer, Karl; Faber, Cornelius; Wiendl, Heinz; Luger, Thomas A.; Meuth, Sven G. & Loser, Karin
  
• Modifying the 5'-Cap for Click Reactions of Eukaryotic mRNA and To Tune Translation Efficiency in Living Cells. Angew Chem Int Ed Engl. 2016; 55: 10899-10903
  Holstein, Josephin M.; Anhäuser, Lea & Rentmeister, Andrea
  
• Protection from septic peritonitis by rapid neutrophil recruitment through omental high endothelial venules. Nat Commun. 2016; 7: 10828
  Buscher, Konrad; Wang, Huiyu; Zhang, Xueli; Striewski, Paul; Wirth, Benedikt; Saggu, Gurpanna; Lütke-Enking, Stefan; Mayadas, Tanya N.; Ley, Klaus; Sorokin, Lydia & Song, Jian
  
• Radiolabeled Selective Matrix Metalloproteinase 13 (MMP-13) Inhibitors: (Radio)Syntheses and in Vitro and First in Vivo Evaluation. J Med Chem. 2017; 60: 307-321
  Hugenberg, Verena; Wagner, Stefan; Kopka, Klaus; Schäfers, Michael; Schuit, Robert C.; Windhorst, Albert D. & Hermann, Sven
  
• Repulsive cues combined with physical barriers and cell-cell adhesion determine progenitor cell positioning during organogenesis. Nat Commun. 2016; 7: 11288
  Paksa, Azadeh; Bandemer, Jan; Hoeckendorf, Burkhard; Razin, Nitzan; Tarbashevich, Katsiaryna; Minina, Sofia; Meyen, Dana; Biundo, Antonio; Leidel, Sebastian A.; Peyrieras, Nadine; Gov, Nir S.; Keller, Philipp J. & Raz, Erez
  
• Repulsive Epithelial Cues Direct Glial Migration along the Nerve. Dev Cell. 2016; 39: 696-707
  Sasse, Sofia & Klämbt, Christian
  
• Staccato/Unc-13-4 controls secretory lysosome-mediated lumen fusion during epithelial tube anastomosis. Nat Cell Biol. 2016; 18: 727-739
  Caviglia, Sara; Brankatschk, Marko; Fischer, Elisabeth J.; Eaton, Suzanne & Luschnig, Stefan
  
• A central region in the minor capsid protein of papillomaviruses facilitates viral genome tethering and membrane penetration for mitotic nuclear entry. PLoS Pathog. 2017; 13: e1006308
  Aydin, Inci; Villalonga-Planells, Ruth; Greune, Lilo; Bronnimann, Matthew P.; Calton, Christine M.; Becker, Miriam; Lai, Kun-Yi; Campos, Samuel K.; Schmidt, M. Alexander & Schelhaas, Mario
  
• A Novel Mouse Model of Staphylococcus aureus Vascular Graft Infection: Noninvasive Imaging of Biofilm Development in Vivo. Am J Pathol. 2017; 187: 268-279
  Van de Vyver, Hélène; Bovenkamp, Philipp R.; Hoerr, Verena; Schwegmann, Katrin; Tuchscherr, Lorena; Niemann, Silke; Kursawe, Laura; Grosse, Christina; Moter, Annette; Hansen, Uwe; Neugebauer, Ute; Kuhlmann, Michael T.; Peters, Georg; Hermann, Sven & Löffler, Bettina
  
• An Evolutionarily Conserved Role for Polydom/Svep1 During Lymphatic Vessel Formation. Circ Res. 2017; 120: 1263-1275
  Karpanen, Terhi; Padberg, Yvonne; van de Pavert, Serge A.; Dierkes, Cathrin; Morooka, Nanami; Peterson-Maduro, Josi; van de Hoek, Glenn; Adrian, Max; Mochizuki, Naoki; Sekiguchi, Kiyotoshi; Kiefer, Friedemann; Schulte, Dörte & Schulte-Merker, Stefan
  
• An FIM-Based Long-Term In-Vial Monitoring System for Drosophila Larvae. IEEE Trans Biomed Eng. 2017; 64: 1862-1874
  Berh, Dimitri; Risse, Benjamin; Michels, Tim; Otto, Nils; Jiang, Xiaoyi & Klambt, Christian
  
• Bleb Expansion in Migrating Cells Depends on Supply of Membrane from Cell Surface Invaginations. Dev Cell. 2017; 43: 577-587.e5
  Goudarzi, Mohammad; Tarbashevich, Katsiaryna; Mildner, Karina; Begemann, Isabell; Garcia, Jamie; Paksa, Azadeh; Reichman-Fried, Michal; Mahabaleshwar, Harsha; Blaser, Heiko; Hartwig, Johannes; Zeuschner, Dagmar; Galic, Milos; Bagnat, Michel; Betz, Timo & Raz, Erez
  
• Cell-matrix signals specify bone endothelial cells during developmental osteogenesis. Nat Cell Biol. 2017; 19: 189-201
  Langen, Urs H.; Pitulescu, Mara E.; Kim, Jung Mo; Enriquez-Gasca, Rocio; Sivaraj, Kishor K.; Kusumbe, Anjali P.; Singh, Amit; Di Russo, Jacopo; Bixel, M. Gabriele; Zhou, Bin; Sorokin, Lydia; Vaquerizas, Juan M. & Adams, Ralf H.
  
• Combined PET Imaging of the Inflammatory Tumor Microenvironment Identifies Margins of Unique Radiotracer Uptake. Cancer Res. 2017; 77: 1831-1841
  Zinnhardt, Bastian; Pigeon, Hayet; Thézé, Benoit; Viel, Thomas; Wachsmuth, Lydia; Fricke, Inga B.; Schelhaas, Sonja; Honold, Lisa; Schwegmann, Katrin; Wagner, Stefan; Faust, Andreas; Faber, Cornelius; Kuhlmann, Michael T.; Hermann, Sven; Schäfers, Michael; Winkeler, Alexandra & Jacobs, Andreas H.
  
• Dll4 and Notch signalling couples sprouting angiogenesis and artery formation. Nat Cell Biol. 2017; 19: 915-927
  Pitulescu, Mara E.; Schmidt, Inga; Giaimo, Benedetto Daniele; Antoine, Tobiah; Berkenfeld, Frank; Ferrante, Francesca; Park, Hongryeol; Ehling, Manuel; Biljes, Daniel; Rocha, Susana F.; Langen, Urs H.; Stehling, Martin; Nagasawa, Takashi; Ferrara, Napoleone; Borggrefe, Tilman & Adams, Ralf H.
  
• Endoglin controls blood vessel diameter through endothelial cell shape changes in response to haemodynamic cues. Nat Cell Biol. 2017; 19: 653-665
  Sugden, Wade W.; Meissner, Robert; Aegerter-Wilmsen, Tinri; Tsaryk, Roman; Leonard, Elvin V.; Bussmann, Jeroen; Hamm, Mailin J.; Herzog, Wiebke; Jin, Yi; Jakobsson, Lars; Denz, Cornelia & Siekmann, Arndt F.
  
• Endothelial Notch signalling limits angiogenesis via control of artery formation. Nat Cell Biol. 2017; 19: 928-940
  Hasan, Sana S.; Tsaryk, Roman; Lange, Martin; Wisniewski, Laura; Moore, John C.; Lawson, Nathan D.; Wojciechowska, Karolina; Schnittler, Hans & Siekmann, Arndt F.
  
• FIM2c : A Multicolour, Multipurpose Imaging System to Manipulate and Analyse Animal Behaviour. IEEE Trans Biomed Eng. 2017; 64: 610-620
  Risse, Benjamin; Otto, Nils; Berh, Dimitri; Jiang, Xiaoyi; Kiel, Matthias & Klambt, Christian
  
• FIMTrack: An open source tracking and locomotion analysis software for small animals. PLoS Comput Biol. 2017; 13: e1005530
  Risse, Benjamin; Berh, Dimitri; Otto, Nils; Klämbt, Christian & Jiang, Xiaoyi
  
• Generic wound signals initiate regeneration in missing-tissue contexts. Nat Commun. 2017; 8: 2282
  Owlarn, Suthira; Klenner, Felix; Schmidt, David; Rabert, Franziska; Tomasso, Antonio; Reuter, Hanna; Mulaw, Medhanie A.; Moritz, Sören; Gentile, Luca; Weidinger, Gilbert & Bartscherer, Kerstin
  
• Mutations in KEOPS-complex genes cause nephrotic syndrome with primary microcephaly. Nat Genet. 2017; 49: 1529-1538
  Braun, Daniela A; Rao, Jia; Mollet, Geraldine; Schapiro, David; Daugeron, Marie-Claire; Tan, Weizhen; Gribouval, Olivier; Boyer, Olivia; Revy, Patrick; Jobst-Schwan, Tilman; Schmidt, Johanna Magdalena; Lawson, Jennifer A; Schanze, Denny; Ashraf, Shazia; Ullmann, Jeremy F P; Hoogstraten, Charlotte A; Boddaert, Nathalie; Collinet, Bruno; Martin, Gaëlle; ... & Hildebrandt, Friedhelm
  
• Optimal Micropatterns in 2D Transport Networks and Their Relation to Image Inpainting. Arch Rational Mech Anal. 2018; 228: 279-308
  Brancolini, Alessio; Rossmanith, Carolin & Wirth, Benedikt
  
• PAR-1 promotes microtubule breakdown during dendrite pruning in Drosophila. EMBO J. 2017; 36: 1981-1991
  Herzmann, Svende; Krumkamp, Rafael; Rode, Sandra; Kintrup, Carina & Rumpf, Sebastian
  
• Polarized actin and VE-cadherin dynamics regulate junctional remodelling and cell migration during sprouting angiogenesis. Nat Commun. 2017; 8 (1): 2210
  Cao, Jiahui; Ehling, Manuel; März, Sigrid; Seebach, Jochen; Tarbashevich, Katsiaryna; Sixta, Tomas; Pitulescu, Mara E.; Werner, Ann-Cathrin; Flach, Boris; Montanez, Eloi; Raz, Erez; Adams, Ralf H. & Schnittler, Hans
  
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