Project Details
Projekt
Structure-activity-relationships of biologically or catalytically active species from the determination of the 3D structure by NMR
Applicant
Professorin Dr. Christina Marie Thiele
Subject Area
Analytical Chemistry
Term
from 2011 to 2016
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 44192252
The focus of the Emmy Noether junior research group lies on the determination of the 3D structure of organic compounds and biologically active species by NMR spectroscopy (in orienting media). Information on the solution conformation and relative configuration is usually obtained from the angular dependence of 3J couplings and the distance dependence of the NOE. During the last eight years an additional NMR parameter, the residual dipolar coupling (RDC), was introduced. There are, however, hitherto very few applications on conformationally flexible compounds and on the determination of the absolute configuration. These aspects as well as the necessary methodological developments (in terms of alignment media, treatment of flexibility and determination of absolute configuration) will be covered within this junior research group.
DFG Programme
Research Units
