Hydrogele auf starPEG-Heparin-Basis zur Stimulation der Angiogenese

• Applicant: Professor Dr. Carsten Werner
• Subject Area: Biological and Biomimetic Chemistry
• Term: from 2005 to 2012
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 19801004

• Final Report Year: 2012

Final Report Abstract

In summary, starPEG-heparin hydrogels providing controlled release of pro-angiogenic cytokines can be successfully applied in angiogenic tissue engineering. For that, the possibility to decouple their mechanical properties from the biofunctionalization is advantageous to precisely adjust various different material parameters, with the option to deliver several growth factors in parallel being of particular benefit for therapeutic angiogenesis.

Publications

• FGF-2 and VEGF functionalization of starPEG-heparin hydrogels to modulate biomolecular and physical cues of angiogenesis. Biomaterials 2010;31(31)7985-7994
  Zieris A, Prokoph S, Levental KR, Welzel PB,Grimmer M, Freudenberg U, Werner C
  
• Dual independent delivery of pro-angiogenic growth factors from starPEG-heparIn hydrogels. J Control Release 2011;156(1):28-36
  Zieris A, Chwaiek K, Prokoph S, Levental KR, Welzel PB, Freudenberg U, Werner C.
  
• Two-tier hydrogel degradation to boost endothelial cell morphogenesis. Biomaterials 2011;32(36):9649-9657
  Chwalek K, Levental KR, Tsurkan MV, Zieris A, Freudenberg U, Werner C