Structure-dynamics-function in photoswitchable proteins (B10)

• Subject Area: Experimental Condensed Matter Physics
• Term: from 2011 to 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 28586557

Targeting the very short and short living structures of the various intermediates formed in reversibly photoswitchable fluorescent proteins during their photo life cycle is the major aim of project B10. Technically, we will face this ambitious goal by applying novel and state of the art time-resolved x-ray scattering and time-resolved x-ray diffraction experiments at synchrotron and FEL sources. We will utilize the structural dynamics data to develop novel and optimized variants of reversibly photoswitchable fluorescent proteins for applications in super-resolution microscopy.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 755: Nanoscale Photonic Imaging
• Applicant Institution: Georg-August-Universität Göttingen
• Project Heads: Professor Dr. Stefan Jakobs; Professorin Dr. Simone Techert