Dying cell-derived find-me signals in leukocyte recruitment (B06)

• Subject Area: Immunology
• Term: from 2011 to 2015
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 165054336

Recent evidence suggests that immune mechanisms contribute to the outcome of cancer radiotherapy. In the proposed project, the release of 'find-me' signals by irradiated cancer cells and the trafficking of antigen presenting cells (APCs) will be studied with focus on the contribution of these mechanisms to the radiotherapeutic success. Specifically, we want to (i) characterize the type of tumor cell death induced by different radiotherapeutic regimes, (ii) dissect the dynamics of intra-tumoral APC recruitment, activation, and lymph node homing, and (iii) assess the contribution of APC-triggered adaptive immune responses to tumor control.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 914: Trafficking of Immune Cells in Inflammation, Development and Disease
• Applicant Institution: Ludwig-Maximilians-Universität München
• Project Head: Professorin Dr. Kirsten Lauber