Molecular mechanisms of miRNA-mediated control of T-cell regeneration after hematopoietic stem cell transplantation (A07)

• Subject Area: Immunology
• Term: from 2011 to 2016
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 24899777

Infectious diseases caused by a prolonged phase of immunodeficiency represents another major clinical problem, which causes morbidity and mortality after hematopoietic stem cell transplantation. Project A7 is searching for possibilities for a faster T-lineage reconstitution. To address this topic, they have investigated markers responsible for directing lineage decision into the T-cell lineages. To this end, they identified several miRNAs with substantial effects on T-cell regeneration. They now aim to identify the relevant target genes using the CRISP/Cas9 technology. In a translational approach, they will use the same CRISPR/Cas9 system to modify target genes in human pre-T-cells.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 738: Optimisation of Conventional and Innovative Transplants
• Applicant Institution: Medizinische Hochschule Hannover
• Project Head: Professor Dr. Andreas Krueger, until 3/2016