ADAM protease activationin the context of IL-6R biology

• Antragsteller: Professor Dr. Jürgen Scheller
• Fachliche Zuordnung: Zellbiologie
• Förderung: Förderung von 2011 bis 2015
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 205822039

• Erstellungsjahr: 2015

Keine Zusammenfassung vorhanden

Projektbezogene Publikationen (Auswahl)

• ADAM17: a molecular switch controlling inflammatory and regenerative responses. Trends in Immunology, Vol. 32. 2011, Issue 8, pp. 380–387.
  Scheller, Jürgen; Chalaris, Athena; Garbers, Christoph & Rose-John, Stefan
  
• Species specificity of ADAM10 and ADAM7 in IL-6 transsignalling and novel role of ADAM10 in inducible IL-6R shedding. Journal of Biological Chemistry, Vol. 286. 2011, pp. 14804-14811.
  Garbers, Christoph; Jänner, Nathalie; Chalaris, Athena; Moss, Marcia L.; Floss, Doreen M.; Meyer, Dörte; Koch-Nolte, Friedrich; Rose-John, Stefan & Scheller, Jürgen
  
• Constitutively Active Mutant gp130 Receptor Protein from Inflammatory Hepatocellular Adenoma Is Inhibited by an Anti-gp130 Antibody That Specifically Neutralizes Interleukin 11 Signalling. Journal of Biological Chemistry, Vol. 287. 2012, pp. 13743-13751.
  Sommer, J.; Effenberger, T.; Volpi, E.; Waetzig, G. H.; Bernhardt, M.; Suthaus, J.; Garbers, C.; Rose-John, S.; Floss, D. M. & Scheller, J.
  
• Plasticity and cross-talk of Interleukin 6-type cytokines. Cytokine & Growth Factor Reviews, Vol. 23. 2012, Issue 3, pp. 85-97.
  Garbers, Christoph; Hermanns, Heike M.; Schaper, Fred; Müller-Newen, Gerhard; Grötzinger, Joachim; Rose-John, Stefan & Scheller, Jürgen
  
• The interleukin 6 pathway and atherosclerosis. The Lancet, Vol. 380. 2012, Issue 9839, pp. 338.
  Scheller, Jürgen & Rose-John, Stefan
  
• The membrane-proximal domain of A Disintegrin and Metalloprotease 17 (ADAM17) is responsible for recognition of the interleukin-6 receptor and interleukin-1 receptor II. FEBS Letters, Vol. 586. 2012, Issue 8, pp. 1093–1100.
  Lorenzen, Inken; Lokau, Juliane; Düsterhöft, Stefan; Trad, Ahmad; Garbers, Christoph; Scheller, Jürgen; Rose-John, Stefan & Grötzinger, Joachim
  
• An interleukin-6 receptor-dependent molecular switch mediates signal transduction of the IL-27 cytokine subunit p28 (IL-30) via a gp130 protein receptor homodimer. Journal of Biological Chemistry, Vol. 288. 2013, pp. 4346-4354.
  Garbers, Christoph; Spudy, Björn; Aparicio-Siegmund, Samadhi; Waetzig, Georg H.; Sommer, Jan; Hölscher, Christoph; Rose-John, Stefan; Grötzinger, Joachim; Lorenzen, Inken & Scheller, Jürgen
  
• Cellular senescence or EGFR signalling induces Interleukin 6 (IL-6) receptor expression controlled by mammalian target of rapamycin (mTOR). Cell Cycle, Vol. 12. 2013, Issue 21, pp. 3421-3432.
  Garbers, Christoph; Kuck, Fabian; Aparicio-Siegmund, Samadhi; Konzak, Kirstin; Kessenbrock, Mareike; Sommerfeld, Annika; Häussinger, Dieter; Lang, Philipp; Brenner, Dirk; Mak, Tak Wah; Rose-John, Stefan; Essmann, Frank; Schulze-Osthoff, Klaus; Piekorz, Roland & Scheller, Jürgen
  
• IL-6 controls the innate immune response against Listeria monocytogenes via classical IL-6 signalling. Journal of Immunology, Vol. 190. 2013 , Issue 2, pp. 703-711.
  Hoge, Judith; Yan, Isabell; Jänner, Nathalie; Schumacher, Valéa; Chalaris, Athena; Steinmetz, Oliver M.; Engel, Daniel R.; Scheller, Jürgen; Rose-John, Stefan & Mittrücker, Hans-Willi
  
• Interleukin-6 and interleukin-11: same same but different. Biological Chemistry, Vol. 394.2013, Issue 9, pp. 1145-1161.
  Garbers, Christoph & Scheller, Jürgen
  
• Recombinant IL-6 treatment protects mice from organ specific autoimmune disease by IL-6 classical signalling-dependent IL-1ra induction. Journal of Autoimmunity, Vol. 40. 2013, pp. 74-85.
  Samavedam, Unni Krishna S.R.L.; Kalies, Kathrin; Scheller, Jürgen; Sadeghi, Hengameh; Gupta, Yask; Jonkman, Marcel F.; Schmidt, Enno; Westermann, Jürgen; Zillikens, Detlef; Rose-John, Stefan & Ludwig, Ralf J.
  
• A Disintegrin And Metalloprotease-17 Dynamic interaction sequence (CANDIS) - the sweet tooth for the human interleukin-6 receptor. Journal of Biological Chemistry, Vol. 289, pp. 16336-16348.
  Düsterhöft, Stefan; Höbel, Katharina; Oldefest, Mirja; Lokau, Juliane; Waetzig, Georg H.; Chalaris, Athena; Garbers, Christoph; Scheller, Jürgen; Rose-John, Stefan; Lorenzen, Inken & Grötzinger, Joachim
  
• Alternative intronic polyadenylation generates the interleukin-6 trans-signalling inhibitor sgp130-E10. Journal of Biological Chemistry, Vol. 289. 2014, pp. 22140-22150.
  Sommer, Jan; Garbers, Christoph; Wolf, Janina; Trad, Ahmad; Moll, Jens M.; Sack, Markus; Fischer, Rainer; Grötzinger, Joachim; Waetzig, Georg H.; Floss, Doreen M. & Scheller, Jürgen
  
• IL-6 Regulates Neutrophil Microabscess Formation in IL-17A-Driven Psoriasiform Lesions. Journal of Investigative Dermatology, Vol. 134. 2014, Issue 3, pp. 728-735.
  Croxford, Andrew L.; Karbach, Susanne; Kurschus, Florian C.; Wörtge, Simone; Nikolaev, Alexei; Yogev, Nir; Klebow, Sabrina; Schüler, Rebecca; Reissig, Sonja; Piotrowski, Carolin; Brylla, Elke; Bechmann, Ingo; Scheller, Jürgen; Rose-John, Stefan; Thomas Wunderlich, F.; Münzel, Thomas; von Stebut, Esther & Waisman, Ari
  
• Inhibition of protein kinase II (CK2) prevents induced signal transducer and activator of transcription (STAT) 1/3 and constitutive STAT3 activation. Oncotarget Vol 5. 2014, No 8, pp. 2131-2148.
  Aparicio-Siegmund, Samadhi; Sommer, Jan; Monhasery, Niloufar; Schwanbeck, Ralf; Keil, Eric; Finkenstädt, David; Pfeffer, Klaus; Rose-John, Stefan; Scheller, Jürgen & Garbers, Christoph
  
• Interleukin-6, but not the interleukin-6 receptor plays a role in recovery from dextran sodium sulfate-induced colitis. International Journal of Molecular Medicine, Vol. 34.2014, Issue 3, pp. 651-660.
  SOMMER, JAN; ENGELOWSKI, ERIKA; BARAN, PAUL; GARBERS, CHRISTOPH; FLOSS, DOREEN M. & SCHELLER, JÜRGEN
  
• Interleukin-6: from Basic biology to selective blockade of pro-inflammatory activities. Seminars in Immunology, Vol. 26. 2014, Issue 1, pp. 2-12.
  Scheller, Jürgen; Garbers, Christoph & Rose-John, Stefan
  
• Recombinant p35 from bacteria can form Interleukin (IL-)12, but Not IL-35. PLoS One, Vol. 9 2014, Issue 9: e107990.
  Aparicio-Siegmund, Samadhi; Moll, Jens M.; Lokau, Juliane; Grusdat, Melanie; Schröder, Jutta; Plöhn, Svenja; Rose-John, Stefan; Grötzinger, Joachim; Lang, Philipp A.; Scheller, Jürgen & Garbers, Christoph
  
• The interleukin-6 receptor Asp358Ala single nucleotide polymorphism rs2228145 confers increased proteolytic conversion rates by ADAM proteases. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Vol. 1842. 2014, Issue 9, pp. 1485-1494.
  Garbers, Christoph; Monhasery, Niloufar; Aparicio-Siegmund, Samadhi; Lokau, Juliane; Baran, Paul; Nowell, Mari A.; Jones, Simon A.; Rose-John, Stefan & Scheller, Jürgen
  
• The role of metalloproteinase ADAM17 in regulating ICOS ligand-mediated humoral immune responses. The Journal of Immunology, Vol. 193. 2014, Issue 6, pp. 2753-2763.
  Marczynska, Joanna; Ozga, Aleksandra; Wlodarczyk, Agnieszka; Majchrzak-Gorecka, Monika; Kulig, Paulina; Banas, Magdalena; Michalczyk-Wetula, Dominika; Majewski, Pawel; Hutloff, Andreas; Schwarz, Jeanette; Chalaris, Athena; Scheller, Jürgen; Rose-John, Stefan & Cichy, Joanna