ADAM protease activationin the context of IL-6R biology

• Applicant: Professor Dr. Jürgen Scheller
• Subject Area: Cell Biology
• Term: from 2011 to 2015
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 205822039

• Final Report Year: 2015

Final Report Abstract

No abstract available

Publications

• ADAM17: a molecular switch controlling inflammatory and regenerative responses. Trends in Immunology, Vol. 32. 2011, Issue 8, pp. 380–387.
  Scheller, J., Chalaris, A., Garbers, C., Rose-John, S.
  
• Species specificity of ADAM10 and ADAM7 in IL-6 transsignalling and novel role of ADAM10 in inducible IL-6R shedding. Journal of Biological Chemistry, Vol. 286. 2011, pp. 14804-14811.
  Garbers, C., Jänner, N., Chalaris, A., Moss, M. L., Floss, D. M., Meyer, D., Koch-Nolte, F., Rose-John, S., Scheller, J.
  
• Constitutively Active Mutant gp130 Receptor Protein from Inflammatory Hepatocellular Adenoma Is Inhibited by an Anti-gp130 Antibody That Specifically Neutralizes Interleukin 11 Signalling. Journal of Biological Chemistry, Vol. 287. 2012, pp. 13743-13751.
  Sommer, J., Effenberger, T., Volpi, E., Waetzig, G. H., Bernhardt, M., Suthaus, J., Garbers, C., Rose-John, S., Floss, D. M., and Scheller, J.
  
• Plasticity and cross-talk of Interleukin 6-type cytokines. Cytokine & Growth Factor Reviews, Vol. 23. 2012, Issue 3, pp. 85-97.
  Garbers, C., Hermanns, H. M., Schaper, F., Müller-Newen, G., Grötzinger, J., Rose-John, S., and Scheller, J.
  
• The interleukin 6 pathway and atherosclerosis. The Lancet, Vol. 380. 2012, Issue 9839, pp. 338.
  Scheller, J., Rose-John, S.
  
• The membrane-proximal domain of A Disintegrin and Metalloprotease 17 (ADAM17) is responsible for recognition of the interleukin-6 receptor and interleukin-1 receptor II. FEBS Letters, Vol. 586. 2012, Issue 8, pp. 1093–1100.
  Lorenzen, I., Lokau, J., Düsterhöft, S., Trad, A., Garbers, C., Scheller, J., Rose-John, S., and Grötzinger, J.
  
• An interleukin-6 receptor-dependent molecular switch mediates signal transduction of the IL-27 cytokine subunit p28 (IL-30) via a gp130 protein receptor homodimer. Journal of Biological Chemistry, Vol. 288. 2013, pp. 4346-4354.
  Garbers, C., Spudy, B., Aparicio-Siegmund, S., Waetzig, G. H., Sommer, J., Hölscher, C., Rose-John, S., Grötzinger, J., Lorenzen, I., and Scheller, J.
  
• Cellular senescence or EGFR signalling induces Interleukin 6 (IL-6) receptor expression controlled by mammalian target of rapamycin (mTOR). Cell Cycle, Vol. 12. 2013, Issue 21, pp. 3421-3432.
  Garbers, C., Kuck, F., Aparicio-Siegmund, S., Konzak, K., Kessenbrock, M., Sommerfeld, A., Häussinger, D., Lang, P. A., Brenner, D., Mak, T. W., Rose-John, S., Essmann, F., Schulze-Osthoff, K., Piekorz, R. P., and J., S.
  
• IL-6 controls the innate immune response against Listeria monocytogenes via classical IL-6 signalling. Journal of Immunology, Vol. 190. 2013 , Issue 2, pp. 703-711.
  Hoge, J., Yan, I., Jänner, N., Schumacher, V., Chalaris, A., Steinmetz, O. M., Engel, D. R., Scheller, J., Rose-John, S., Mittrücker, H. W.
  
• IL-6 Regulates Neutrophil Microabscess Formation in IL-17A-Driven Psoriasiform Lesions. Journal of Investigative Dermatology, Vol. 134. 2014, Issue 3, pp. 728-735.
  Croxford, A. L., Karbach, S., Kurschus, F. C., Wörtge, S., Nikolaev, A., Yogev, N., Klebow, S., Schüler, R., Reissig, S., Piotrowski, C., Brylla, E., Bechmann, I., Scheller, J., Rose-John, S., Wunderlich, F. T., Münzel, T., von Stebut, E., Waisman, A.
  
• Interleukin-6 and interleukin-11: same same but different. Biological Chemistry, Vol. 394.2013, Issue 9, pp. 1145-1161.
  Garbers C. S. J.
  
• Recombinant IL-6 treatment protects mice from organ specific autoimmune disease by IL-6 classical signalling-dependent IL-1ra induction. Journal of Autoimmunity, Vol. 40. 2013, pp. 74-85.
  Samavedam, U. K., Kalies, K., Scheller, J., Sadeghi, H., Gupta, Y., Jonkman, M. F., Schmidt, E., Westermann, J., Zillikens, D., Rose-John, S., Ludwig, R. J.
  
• A Disintegrin And Metalloprotease-17 Dynamic interaction sequence (CANDIS) - the sweet tooth for the human interleukin-6 receptor. Journal of Biological Chemistry, Vol. 289, pp. 16336-16348.
  Düsterhöft, S., Höbel, K., Oldefest, M., Lokau, J., Waetzig, G. H., Chalaris, A., Garbers, C., Scheller, J., Rose-John, S., Lorenzen, I., and Grötzinger, J.
  
• Alternative intronic polyadenylation generates the interleukin-6 trans-signalling inhibitor sgp130-E10. Journal of Biological Chemistry, Vol. 289. 2014, pp. 22140-22150.
  Sommer, J., Garbers, C., Wolf, J., Trad, A., Moll, J. M., Sack, M., Fischer, R., Grötzinger, J., Waetzig, G. H., Floss, D. M., Scheller, J.
  
• Inhibition of protein kinase II (CK2) prevents induced signal transducer and activator of transcription (STAT) 1/3 and constitutive STAT3 activation. Oncotarget Vol 5. 2014, No 8, pp. 2131-2148.
  Aparicio-Siegmund, S., Sommer, J., Monhasery, N., Schwanbeck, R., Keil, E., Finkenstädt, D., Pfeffer, K., Rose-John, S., Scheller, J., Garbers, C.
  
• Interleukin-6, but not the interleukin-6 receptor plays a role in recovery from dextran sodium sulfate-induced colitis. International Journal of Molecular Medicine, Vol. 34.2014, Issue 3, pp. 651-660.
  Sommer, J., Engelowski, E., Baran, P., Garbers, C., Floss, D. M., Scheller, J.
  
• Interleukin-6: from Basic biology to selective blockade of pro-inflammatory activities. Seminars in Immunology, Vol. 26. 2014, Issue 1, pp. 2-12.
  Scheller, J., Garbers, C., Rose-John, S.
  
• Recombinant p35 from bacteria can form Interleukin (IL-)12, but Not IL-35. PLoS One, Vol. 9 2014, Issue 9: e107990.
  Aparicio-Siegmund, S., Moll, J. M., Lokau, J., Grusdat, M., Schröder, J., Plöhn, S., Rose-John, S., Grötzinger, J., Lang, P. A., Scheller, J., Garbers, C.
  
• The interleukin-6 receptor Asp358Ala single nucleotide polymorphism rs2228145 confers increased proteolytic conversion rates by ADAM proteases. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Vol. 1842. 2014, Issue 9, pp. 1485-1494.
  Garbers, C., Monhasery, N., Aparicio-Siegmund, S., Lokau, J., Baran, P., Nowell, M. A., Jones, S. A., Rose-John, S., Scheller, J.
  
• The role of metalloproteinase ADAM17 in regulating ICOS ligand-mediated humoral immune responses. The Journal of Immunology, Vol. 193. 2014, Issue 6, pp. 2753-2763.
  Marczynska, J., Ozga, A., Wlodarczyk, A., Majchrzak-Gorecka, M., Kulig, P., Banas, M., Michalczyk-Wetula, D., Majewski, P., Hutloff, A., Schwarz, J., Chalaris, A., Scheller, J., Rose-John, S., Cichy, J.