Syntheses of complex glycoligands and characterization of multivalent C-type lectinreceptor/carbohydrate-interactions (B08)

• Subject Area: Biological and Biomimetic Chemistry
• Term: from 2012 to 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 32049920

The project B8 focuses on the biophysical and biological characterization of multivalent carbohydrate-carbohydrate interactions. Relevant carbohydrates will be synthesized and functionalized on the surface of nanoparticles to increase binding avidity. Tumor-specific carbohydrate antigens will be synthesized and the carbohydrate interactions between GM3 and Gg3 as well as GB4 and GalGB4 will be evaluated for their suitability for tumor cell-specific imaging. Further carbohydrate structures such as the heteroxylans will be prepared by automated solid-phase synthesis and the impact of a multivalent carbohydrate presentation on the interaction will be investigated.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 765: Multivalency as Chemical Organisation and Action Principle: New Architectures, Functions and Applications
• Applicant Institution: Freie Universität Berlin
• Co-Applicant Institution: Max-Planck-Institut für Kolloid- und Grenzflächenforschung ; Abteilung Biomolekulare Systeme
• Project Heads: Professor Dr. Bernd Lepenies, until 12/2015; Professor Dr. Peter H. Seeberger