Functional role of skin resident effector memory T cells in host protection against infections and behaviour in healthy skin and cutaneous lymphomas.

• Applicant: Dr. Emmanuella Guenova-Hötzenecker
• Subject Area: Dermatology
• Term: from 2012 to 2014
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 209176247

• Final Report Year: 2015

Final Report Abstract

No abstract available

Publications

• Low dose high-dose-rate brachytherapy in the treatment of facial lesions in cutaneous T-cell lymphoma. J Am Acad Dermatol 2013 69(1):61-5
  DeSimone JA, Guenova E, Carter JB, Chaney KS, Aldridge JR, Noell CM, Dorosario AA, Hansen JL, Kupper TS, Devlin PM
  
• Th2 cytokines from malignant cells suppress Th1 responses and enforce a global Th2 bias in leukemic cutaneous T-cell lymphoma. Clin Cancer Res. 2013 19(14):3755-63
  Guenova E, Watanabe R, Teague JE, Desimone JA, Jiang Y, Dowlatshahi M, Schlapbach C, Schaekel K, Rook AH, Tawa M, Fisher DC, Kupper TS, Clark RA
  (See online at https://doi.org/10.1158/1078-0432.CCR-12-3488)
• Cutaneous Innate Immune Sensing of Toll-like Receptor 2-6 Ligands Suppresses T Cell Immunity by Inducing Myeloid-Derived Suppressor Cells. Immunity. 2014 41(5):762-75
  Skabytska Y, Wölbing F, Günther C, Köberle M, Kaesler S, Chen KM, Guenova E, Demircioglu D, Kempf WE, Volz T, Rammensee HG, Schaller M, Röcken M, Götz F, Biedermann T
  (See online at https://doi.org/10.1016/j.immuni.2014.10.009)
• Human Th9 cells are skin-tropic and have autocrine and paracrine pro-inflammatory capacity. Sci Transl Med 2014 6(219):219ra8
  Schlapbach C, Gehad A, Yang C, Watanabe R, Guenova E, Teague JE, Campbell L, Yawalkar N, Kupper TS, Clark RA
  (See online at https://doi.org/10.1126/scitranslmed.3007828)
• Systemic corticosteroids for subcutaneous panniculitis-like T-cell lymphoma. Br J Dermatol 2014 171(4):891-4
  Guenova E, Schanz S, Hoetzenecker W, Desimone JA, Mehra T, Voykov B, Urosevic- Maiwald M, Berneburg M, Dummer R, French LE, Kerl K, Kamarachev J, Fierlbeck G, Cozzio A
  (See online at https://doi.org/10.1111/bjd.13053)
• IL-4 abrogates TH17 cell-mediated inflammation by selective silencing of IL-23 in antigen-presenting cells. Proc Natl Acad Sci USA. 2015 112(7):2163-8
  Guenova E, Skabytska Y, Hoetzenecker W, Weindl G, Sauer K, Tham M, Kim KW, Park JH, Seo JH, Ignatova D, Cozzio A, Levesque MP, Volz T, Köberle M, Kaesler S, Thomas P, Mailhammer R, Ghoreschi K, Schäkel K, Amarov B, Eichner M, Schaller M, Clark RA, Röcken M, Biedermann T
  (See online at https://doi.org/10.1073/pnas.1416922112)