Long-range GABAergic cells

• Antragstellerin: Professorin Dr. Hannah Monyer
• Fachliche Zuordnung: Molekulare Biologie und Physiologie von Nerven- und Gliazellen
• Förderung: Förderung von 2012 bis 2015
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 212160449

• Erstellungsjahr: 2016

Zusammenfassung der Projektergebnisse

With the support of this grant we successfully finished three projects. We studied combined anterograde and retrograde tracing with slice electrophysiology and optogenetics, and functionally characterized novel long-range GABAergic projections that connect the septum with the MEC. Prompted by the preponderant inhibitory connectivity in the MEC, we investigated the neighboring structure, i.e. the LEC, and demonstrated that the MEC and LEC exhibit similar principles of connectivity with upstream and downstream structures. Finally, we extended our investigations of long-range GABAergic neurons to other brain regions, and characterized in detail distinct PV+ and Calbindin+ neurons that connect the motor cortex with the striatum.

Projektbezogene Publikationen (Auswahl)

• Local and distant input controlling excitation in layer II of the medial entorhinal cortex. Neuron 89: 1-15 (2016)
  Fuchs, E.C., Neitz, A., Pinna, R., Melzer, S., Caputi, A., Monyer, H.
  (Siehe online unter https://doi.org/10.1016/j.neuron.2015.11.029)
• Spatially segregated feedforward and feedback neurons support differential odor processing in the lateral entorhinal cortex. Nat Neurosci. 19(7): 935-944 (2016)
  Leitner, F.C., Melzer, S., Lutcke, H., Pinna, R., Seeburg, P.H., Helmchen, F., Monyer, H.
  (Siehe online unter https://doi.org/10.1038/nn.4303)