Long-range GABAergic cells

• Applicant: Professorin Dr. Hannah Monyer
• Subject Area: Molecular Biology and Physiology of Neurons and Glial Cells
• Term: from 2012 to 2015
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 212160449

• Final Report Year: 2016

Final Report Abstract

With the support of this grant we successfully finished three projects. We studied combined anterograde and retrograde tracing with slice electrophysiology and optogenetics, and functionally characterized novel long-range GABAergic projections that connect the septum with the MEC. Prompted by the preponderant inhibitory connectivity in the MEC, we investigated the neighboring structure, i.e. the LEC, and demonstrated that the MEC and LEC exhibit similar principles of connectivity with upstream and downstream structures. Finally, we extended our investigations of long-range GABAergic neurons to other brain regions, and characterized in detail distinct PV+ and Calbindin+ neurons that connect the motor cortex with the striatum.

Publications

• Local and distant input controlling excitation in layer II of the medial entorhinal cortex. Neuron 89: 1-15 (2016)
  Fuchs, E.C., Neitz, A., Pinna, R., Melzer, S., Caputi, A., Monyer, H.
  (See online at https://doi.org/10.1016/j.neuron.2015.11.029)
• Spatially segregated feedforward and feedback neurons support differential odor processing in the lateral entorhinal cortex. Nat Neurosci. 19(7): 935-944 (2016)
  Leitner, F.C., Melzer, S., Lutcke, H., Pinna, R., Seeburg, P.H., Helmchen, F., Monyer, H.
  (See online at https://doi.org/10.1038/nn.4303)