Modulation of spike generation in somatosensory endings of the cornea - the role of chloride currents in inflammatory sensitization
Final Report Abstract
Due to unexpected competition, the original project has been redirected to fit into the newly established SFB 1158 “From nociception to chronic pain” where our project is now conducted under the title “Structural and functional interactions between nociceptive and non-nociceptive systems within the spinal trigeminal nucleus”. The topic is no longer restricted to chloride-based neuromodulation, but all types of modulatory input into the nociceptive trigeminal system are being considered. The aim is to study modulatory effects of non-nociceptive systems in cornea, Dura mater and nasal epithelia upon afferent signal processing in the trigeminal system. These interactions include neuropeptidergic effects in the periphery, modulation of interneuron networks, as well as the convergence of afferents onto secondary neurons in the spinal trigeminal nucleus. The theme is thus changed from inflammatory plasticity to trigeminal neuromodulation in general.
Publications
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(2013) Targeted expression of anoctamin calcium-activated chloride channels in rod photoreceptor terminals of the rodent retina. Invest Ophthalmol Vis Sci 54: 3126-36
Dauner K, Möbus C, Frings S, Möhrlen F
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TTX-resistant action potential conduction in cultured porcine DRG neurites. Society for Neuroscience. November 9-11, 2013, San Diego, California
Carr RW; Jonas R; Klusch A; Petersen M; Schmelz M
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Effects of NGF and GDNF on NaV mediated conduction in cultured porcine DRG neurites. 15th World Congress on Pain (IASP), October 6–11, 2014, Buenos Aires, Argentina
Jonas R; Klusch A; De Col R; Schmelz M; Petersen M; Carr RW
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Processing and modulation of the primary olfactory signal. Society of General Physiologists, September 2-6, 2014, Woods Hole, Mass., USA
Genovese F, Bauersachs HG, Möhrlen F, Frings S
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(2015) Assessment of TTX-s and TTX-r Action Potential Conduction along Neurites of NGF and GDNF Cultured Porcine DRG Somata. PLoS ONE 10, e0139107
Jonas R, Klusch A, Schmelz M, Petersen M, Carr RW
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(2016) Properties of an optogenetic model for olfactory stimulation. J Physiol.
Genovese F, Thews M, Möhrlen F, Frings S
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Sodium Channel Nav1.8 Underlies TTX-Resistant Axonal Action Potential Conduction in Somatosensory C-Fibers of Distal Cutaneous Nerves. Journal of Neuroscience 17 May 2017, 37 (20) 5204-5214.
Klein AH, Vyshnevska A, Hartke TV, De Col R, Mankowski J, Turnquist BP, Bosmans F, Reeh PW, Schmelz M, Carr RW, Ringkamp M
