Retrospective Motion Compensation in Optical Coherence Tomography

• Applicant: Professor Dr.-Ing. Joachim Hornegger
• Subject Area: Image and Language Processing, Computer Graphics and Visualisation, Human Computer Interaction, Ubiquitous and Wearable Computing
• Term: from 2013 to 2014
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 213744097

• Final Report Year: 2014

Final Report Abstract

The pursued research reached all the defined goals of the original grant proposal. As a result a fully automatic motion compensation algorithm was developed, implemented, evaluated, presented at major conferences, and published in highly ranked journals. The developed algorithms for motion compensation are developing to be the most applied method in 3-D OCT imaging due to the huge support of Professor Fujimoto with his team and collaborators. The results also show that the explicit modeling of eye rotation is not required to perform motion compensation in OCT. As expected, nonrigid registration covers all types of eye motion within an OCT acquisition cycle.

Publications

• "Handheld ultrahigh speed swept source optical coherence tomography instrument using a MEMS scanning mirror," Biomed Opt Express, Vol. 5, No.1, 293-311, 2013
  C. D. Lu, M. F. Kraus, B. Potsaid, J. J. Liu, W. Choi, V. Jayaraman, A. E. Cable, J. Hornegger, J. S. Duker, and J. G. Fujimoto
  
• (2013). "Automated lamina cribrosa microstructural segmentation in optical coherence tomography scansof healthy and glaucomatous eyes". In: Biomedical Optics Express, Vol. 4, No. 11, pp. 2596-2608
  Nadler, Zach, Bo Wang, Gadi Wollstein, Jessica E. Nevins, Hiroshi Ishikawa, Larry Kagemann, Ian Sigal, R. Daniel Ferguson, Daniel X. Hammer, Ireneusz Grulkowski, Jonathan J. Liu, Martin F. Kraus, Chen D. Lu, Joachim Hornegger, James G. Fujimoto, and Joel S. Schuman
  
• "Quantitative 3D-OCT motion correction with tilt and illumination correction, robust similarity measure and regularization", Biomed Opt Express, Vol. 5, No. 8, p. 2591-2613, Aug. 2014
  M. F. Kraus, J. J. Liu, J. Schottenhamml, C. Chen, A. Budai, L. Branchini, T. Ko, H. Ishikawa, G.Wollstein, J. Schuman, J. S. Duker, J. G. Fujimoto and J. Hornegger
  
• (2014). "En Face Enhanced-Depth Swept-Source Optical Coherence Tomography Features of Chronic Central Serous Chorioretinopathy". In: Ophthalmology 121.3, pp. 719-726
  Ferrara, Daniela, Kathrin J. Mohler, Nadia Waheed, Mehreen Adhi, Jonathan J. Liu, Ireneusz Grulkowski, Martin F. Kraus, Caroline Baumal, Joachim Hornegger, James G. Fujimoto, and Jay S. Duker