The monocyte response to acute myocardial infarction- dynamic changes in monocyte gene expression -
Final Report Abstract
In summary, we report how chronic stress interferes with hematopoiesis and describe interactions between the central nervous system, immunity and atherosclerosis. In mice exposed to stress, increased sympathetic nervous system activity decreased CXCL12 expression in the hematopoietic stem cell niche, accelerated HSC proliferation and enhanced neutrophil and monocyte production. These events caused extensive release of inflammatory leukocytes into the circulation and promoted plaque inflammation. Administration of a β3-adrenergic receptor blocker limited disease progression, supporting the notion that sympathetic nervous system signaling via this receptor and targeting of the CXCL12-CXCR4 interaction in the bone marrow should be explored as potential therapeutic avenues.
Publications
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Chronic variable stress activates hematopoietic stem cells. Nat Med. 2014 Jul;20(7):754-8. Epub 2014 Jun 22
Heidt, Timo; Sager, Hendrik B; Courties, Gabriel; Dutta, Partha; Iwamoto, Yoshiko; Zaltsman, Alex; von zur Muhlen, Constantin; Bode, Christoph; Fricchione, Gregory L; Denninger, John; Lin, Charles P; Vinegoni, Claudio; Libby, Peter; Swirski, Filip K; Weissleder, Ralph & Nahrendorf, Matthias
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Differential contribution of monocytes to heart macrophages in steady-state and after myocardial infarction. Circ Res. 2014 Jul 7;115(2):284-95. Epub 2014 May 1
Heidt, Timo; Courties, Gabriel; Dutta, Partha; Sager, Hendrik B.; Sebas, Matt; Iwamoto, Yoshiko; Sun, Yuan; Da Silva, Nicolas; Panizzi, Peter; van der Laan, Anja M.; Swirski, Filip K.; Weissleder, Ralph & Nahrendorf, Matthias
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In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight. Nat Nanotechnol. 2014 Aug;9(8):648-55. Epub 2014 May 11
Dahlman, James E.; Barnes, Carmen; Khan, Omar F.; Thiriot, Aude; Jhunjunwala, Siddharth; Shaw, Taylor E.; Xing, Yiping; Sager, Hendrik B.; Sahay, Gaurav; Speciner, Lauren; Bader, Andrew; Bogorad, Roman L.; Yin, Hao; Racie, Tim; Dong, Yizhou; Jiang, Shan; Seedorf, Danielle; Dave, Apeksha; Singh Sandhu, Kamaljeet; ... & Anderson, Daniel G.
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Ischemic stroke activates hematopoietic bone marrow stem cells. Circ Res. 2015 Jan 30;116(3):407-17. Epub 2014 Oct 31
Courties, Gabriel; Herisson, Fanny; Sager, Hendrik B.; Heidt, Timo; Ye, Yuxiang; Wei, Ying; Sun, Yuan; Severe, Nicolas; Dutta, Partha; Scharff, Jennifer; Scadden, David T.; Weissleder, Ralph; Swirski, Filip K.; Moskowitz, Michael A. & Nahrendorf, Matthias
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Macrophages retain hematopoietic stem cells in the spleen via VCAM-1. J Exp Med. 2015 Apr 6;212(4):497-512. Epub 2015 Mar 23
Dutta, Partha; Hoyer, Friedrich Felix; Grigoryeva, Lubov S.; Sager, Hendrik B.; Leuschner, Florian; Courties, Gabriel; Borodovsky, Anna; Novobrantseva, Tatiana; Ruda, Vera M.; Fitzgerald, Kevin; Iwamoto, Yoshiko; Wojtkiewicz, Gregory; Sun, Yuan; Da Silva, Nicolas; Libby, Peter; Anderson, Daniel G.; Swirski, Filip K.; Weissleder, Ralph & Nahrendorf, Matthias
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Myocardial Infarction Activates CCR2(+) Hematopoietic Stem and Progenitor Cells. Cell Stem Cell. 2015 May 7;16(5):477-87
Dutta, Partha; Sager, Hendrik B.; Stengel, Kristy R.; Naxerova, Kamila; Courties, Gabriel; Saez, Borja; Silberstein, Lev; Heidt, Timo; Sebas, Matthew; Sun, Yuan; Wojtkiewicz, Gregory; Feruglio, Paolo Fumene; King, Kevin; Baker, Joshua N.; van der Laan, Anja M.; Borodovsky, Anna; Fitzgerald, Kevin; Hulsmans, Maarten; Hoyer, Friedrich; ... & Nahrendorf, Matthias
