Hippocampal functional connectivity during episodic memory formation in humans: The roles of reward- and salience-related dopaminergic brain areas, novelty, and schema-related episodic distinctiveness (A10)

• Subject Area: Metabolism, Biochemistry and Genetics of Microorganisms
• Term: from 2012 to 2015
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 36555331

We will test the influence of stimulus novelty on the one hand and consistency of a stimulus with a preexistingknowledge schema on the other on episodic memory formation in a factorial design usingfMRI.Hereby we will specifically focus on connectivity of the hippocampus with neocortical and withsubcortical dopaminergic brain regions. Motivational dopaminergic regulation of the influences ofthese stimulus properties will be studied by introducing reward and punishment manipulations. Tofurther investigate dopaminergic and serotonergic modulation we will recruit participants according totheir COMT/DAT1 and 5-HTR2a genotypes respectively.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 779: Neurobiology of Motivated Behaviour
• Applicant Institution: Otto-von-Guericke-Universität Magdeburg
• Project Heads: Dr. Christine Eßlinger, until 3/2012; Dr. Christian Kluge; Professor Alan Richardson-Klavehn, Ph.D.; Privatdozent Dr. Björn Hendrik Schott, since 4/2012