Gentransfer in mesenchymale Stammzellen zur Knorpelreparation - Modulation der hypertrophen Chondrogenese und in vivo Applikation

• Applicant: Professor Dr. Andre Steinert
• Subject Area: Orthopaedics, Traumatology, Reconstructive Surgery
• Term: from 2006 to 2012
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 21827687

• Final Report Year: 2012

No abstract available

Publications

• Major biological obstacles for persistent cell-based regeneration of articular cartilage. Arthritis Research & Therapy, Vol. 9. 2007, Issue 3: 213.
  Steinert, Andre F; Ghivizzani, Steven C; Rethwilm, Axel; Tuan, Rocky S; Evans, Christopher H & Nöth, Ulrich
  
• Concepts in gene therapy for cartilage repair. Injury 2008; 39S1: S97-113. [1F:1.509] (Anlage 2) Injury, Vol. 39. 2008, Issue 1, Supplement, pp. 97–113.
  Steinert, Andre F.; Nöth, Ulrich & Tuan, Rocky S.
  
• Technology Insight: adult mesenchymal stem cells for osteoarthritis therapy. Nature Clinical Practice Rheumatology, Vol. 4. 2008, Issue 7, pp. 371-380.
  Nöth, Ulrich; Steinert, Andre F. & Tuan, Rocky S.
  
• Enhanced in vitro chondrogenesis of primary mesenchymal stem cells by combined gene transfer. Tissue Engineering Part A, Vol. 15. 2009, Issue 5, pp. 1127-1139.
  Steinert, Andre F.; Palmer, Glyn D.; Pilapil, Carmencita; Nöth, Ulrich; Evans, Christopher H. & Ghivizzani, Steven C.
  
• Hypertrophy is induced during the in vitro chondrogenic differentiation of human mesenchymal stem cells by bone morphogenetic protein-2 and bone morphogenetic protein-4 gene transfer. Arthritis Research & Therapy, Vol. 11.2009: R148.
  Steinert, Andre F.; Proffen, Benedikt; Kunz, Manuela; Hendrich, Christian; Ghivizzani, Steven C.; Nöth, Ulrich; Rethwilm, Axel; Eulert, Jochen & Evans, Christopher H.
  
• Cell Delivery Therapeutics for Musculoskeletal Regeneration. Advanced Drug Delivery Reviews, Vol. 62. 2010, Issues 7–8, pp. 765–783.
  Nöth, Ulrich; Rackwitz, Lars; Steinert, Andre F. & Tuan, Rocky S.
  
• Concise Review: The Clinical Application of Mesenchymal Stem Cells for Musculoskeletal Regeneration: Current Status and Perspectives. Stem Cells Translational Medicine, Vol. 1. 2012, Number 3, pp. 237-247.
  Steinert, Andre F.; Rackwitz, Lars; Gilbert, Fabian; Nöth, Ulrich & Tuan, Rocky S.
  
• Indian hedgehog gene transfer is a chondrogenic inducer of human mesenchymal stem cells. Arthritis Research & Therapy, Vol. 14. 2012: R168.
  Steinert, Andre F; Weissenberger, Manuel; Kunz, Manuela; Gilbert, Fabian; Ghivizzani, Steven C; Göbel, Sascha; Jakob, Franz; Nöth, Ulrich & Rudert, Maximilian