Project Details
Projekt
Autopenetration of bacterial effector proteins and modulation of signalling responses in cellular barriers (B03)
Subject Area
Medical Microbiology and Mycology, Hygiene, Molecular Infection Biology
Term
from 2012 to 2024
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 194468054
Effector proteins can also enter host cells in a type III secretion system (T3SS)-independent manner thereby widening their potential functional range to modulate cellular barriers. In this regard, we identified the entire group of bacterial leucine-rich repeat (LPX) effector proteins as so far unknown cell-penetrating effector proteins (CPE), which provided further evidence for a general concept of T3SS-independent translocation. Now we will elucidate the effects of this novel class of CPE in modulating immune responses in cell-culture and animal models and explore potential therapeutic applications of these CPE.
DFG Programme
Collaborative Research Centres
Applicant Institution
Universität Münster
Project Heads
Privatdozent Dr. Christian Rüter; Professor Dr. Marcus Alexander Schmidt, until 6/2020
