Dermal stress response and barrier integrity in allergy and autoimmune diseases (B09)

• Subject Area: Immunology
• Term: from 2012 to 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 194468054

The project addresses the role of the pro-inflammatory alarmins S100A8 and S100A9 during dermal inflammation. We have shown that short-term inflammatory activation by S100A8/S100A9 differs significantly from long-term regulatory effects of these proteins. Performing targeted gene editing in immortalized myeloid stem cells we will now investigate which molecular mechanisms and signalling pathways reprogram monocytes and dendritic cells to a regulatory phenotype. We will confirm the relevance of these novel pathways of reprogramming of regulatory myeloid cells in models of dermal inflammation in vivo.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1009: Breaking Barriers - Immune Cells and Pathogens at Cell/Matrix Barriers
• Applicant Institution: Universität Münster
• Project Head: Professor Dr. Johannes Roth