Molecular Basis of Mitochondrial Cardiomyopathies (A06)

• Subject Area: Cell Biology
• Term: from 2012 to 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 193793266

In A06, we assess how two distinct defects in mitochondrial function cause cardiomyopathies. Using different model systems, we will analyze how mitochondrial functions, signaling pathways, and cellular metabolism are altered in Barth syndrome, and how these translate to the disease phenotype. In addition, we will study how the loss of COA6 causes cardiac malfunction. From these models we will identify how mitochondrial pathophysiology may contribute to the development of heart failure.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1002: Modulatory Units in Heart Failure
• Applicant Institution: Georg-August-Universität Göttingen
• Project Head: Professor Dr. Peter Rehling